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Break-induced replication (BIR) mediates single-ended DNA double-strand break (DSB) repair. Upon strand invasion into a homologous repair template, BIR is catalysed by a minimal replisome comprising PCNA, DNA polymerase delta, and the Pif1 helicase. Here, we identify an interaction between Polymeras...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2026-06-15 | PXD074712 | Pride
The multifaceted roles of the DNA polymerase subunit Pol32 in maintaining genome integrity
Strong cellular stress causes wide-spread perturbations in the transcriptome and in several types of DNA/RNA interactions, and through incompletely understood pathways to formation of cytoplasmic stress granules (SGs). We have investigated the relationships between strong transcriptional induction, ...
ORGANISM(S): Saccharomyces cerevisiae 
2021-12-31 | GSE122423 | GEO
The DNA polymerase subunit Pol32 and RNase H1 are required for stress granule formation through R-loop regulation
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