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TranscriptomicsThe exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon ...
ORGANISM(S): Drosophila melanogaster 
2016-08-19 | E-GEOD-81220 | biostudies-arrayexpress
GenomicsCell polarity proteins promote macropinocytosis in response to metabolic stress
Cell polarity proteins promote macropinocytosis in response to metabolic stress
PRJNA1154268 | ENA
GenomicsBEAF-32 insulator regulates gene expression of genes involved in cell polarity and neoplastic growth.
This SuperSeries is composed of the following subset Series: GSE36735: Distribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq] GSE36736: Genome wide transcriptional profiling of BEAF-32 in wing imaginal tissues of wildtype and mutants [expresion array] Refe...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36737 | biostudies-arrayexpress
GenomicsDistribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq]
Chromatin insulators are DNA protein complexes that mediate inter and intra chromosomal interactions. Boundary Element Associated Factor- 32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are ...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36735 | biostudies-arrayexpress
TranscriptomicsCTCF binding polarity determines chromatin looping [4C]
CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional organization of chromatin. In this study, we systematically assayed the 3D genomic contact profiles of hundreds of CTCF binding sites in multiple tissues with high-resolution 4C-seq. We find both developmentall...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-72539 | biostudies-arrayexpress
GenomicsQKI regulated splicing required for cell polarity
QKI regulated splicing required for cell polarity
PRJNA798365 | ENA
ProteomicsBasolateral Protein Scribble Provides Phosphatase PP1 to a Signaling Network Maintaining Apicobasal Polarity
Scribble, a member of the LAP protein family, contributes to the apicobasal polarity (ABP) of epithelial cells. The LAP unique region (LUR) of these proteins is essential for ABP function, and includes a highly conserved Leucine Reach Repeat (LRR) domain. Here we study how the LRR domain of Scribble...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028919 | Pride
Scribble Apicobasal polarity Phosphatase pp1 
TranscriptomicsCell polarity proteins promote macropinocytosis in response to metabolic stress
Macropinocytosis has emerged as a nutrient-scavenging pathway that cancer cells exploit to survive the nutrient-deprived conditions of the tumor microenvironment. Cancer cells are especially reliant on glutamine for their survival, and in pancreatic ductal adenocarcinoma (PDAC) cells, glutamine defi...
ORGANISM(S): Homo sapiens 
2024-10-22 | GSE276007 | GEO
UnknownCiliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
Not available
S-EPMC4302998 | biostudies-literature
UnknownVE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
Not available
S-EPMC5025268 | biostudies-literature
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