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ProteomicsHistone dynamics at replication forks in embryonic stem cells
We employ inducible mutants to dissect the early and late consequences of impaired histone recycling. We find rapid accumulation of H3K27me3 in response to impaired histone recycling, preceding gene expression changes. Simultaneous disruption of both leading (POLE4) and lagging strand (MCM2-2A) recy...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-12 | PXD053300 | Pride
Parental histones Pole4 Mcm2 Escs 
UnknownPOLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.
Not available
S-EPMC6179962 | biostudies-literature
UnknownThe loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity.
Not available
S-EPMC11229324 | biostudies-literature
GenomicsExpression analysis of primary mouse mebryonic fibroblasts lacking the POLE4 and P53 tumour suppressors genes
Expression analysis of primary mouse mebryonic fibroblasts lacking the POLE4 and P53 tumour suppressors genes
PRJNA824790 | ENA
TranscriptomicsExpression analysis of primary mouse mebryonic fibroblasts lacking the POLE4 and P53 tumour suppressors genes
Mouse embryonic fibroblasts lacking the POLE4 subunit of Pol Epsilon show signs of replication stress and DNA damage. Strikingly this phenotype is lost upon deletion of the Trp53 gene. In order to reveal the mechanism responsible for this phenotype we carried oud bulk RNA sequencing from primary mou...
ORGANISM(S): Mus musculus 
2022-05-16 | GSE200475 | GEO
GenomicsDisrupted control of origin activation promotes genomic instability upon loss of POLE4 and disfunction of the TRP53-CDKN1A/P21 tumour suppressor axis.
Disrupted control of origin activation promotes genomic instability upon loss of POLE4 and disfunction of the TRP53-CDKN1A/P21 tumour suppressor axis.
PRJNA824082 | ENA
OtherDisrupted control of origin activation promotes genomic instability upon loss of POLE4 and disfunction of the TRP53-CDKN1A/P21 tumour suppressor axis.
The maintenance of genome stability relies on the coordinated control of origin activation and replication fork progression. How the interplay between these processes impacts human genetic disease and cancer remains incompletely characterized. Here we initially show that mouse cells lacking Pole4 an...
ORGANISM(S): Mus musculus 
2022-05-16 | GSE200331 | GEO
ProteomicsProximal proteomics analysis reveals DNA polymerase δ subunit 3 is a new MCM2 binding partner and promotes
Our TurboID proximity labeling proteomics approach describes a comprehensive analysis of the histone recycling network.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD048030 | Pride
ProteomicsThe genetic and biochemical basis of human leading strand synthesis
The maintenance of genome stability requires efficient leading strand synthesis by DNA Polymerase Epsilon (Pol). By performing CRISPR genetic screens in cells lacking the POLE4 subunit of Pol we define a genetic map of the factors required to support Pol function in the absence of its accessory subu...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD070472 | Pride
The genetic and biochemical basis of human leading strand synthesis 
UnknownPolε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.
Not available
S-EPMC5972231 | biostudies-literature
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