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GenomicsPolyglutamylation of microtubules drives neuronal remodeling
Polyglutamylation of microtubules drives neuronal remodeling
PRJNA1261042 | ENA
ProteomicsAnalysis of DVL3 polyglutamylation using Q-TOF
Polyglutamylation is a reversible post-translational modification initially discovered on tubulin. In eukaryotes, polyglutamylation is catalyzed by enzymes from the tubulin tyrosine ligase-like (TTLL) family, which show substrate and reaction specificities that are so far mostly explored on tubulin....
ORGANISM(S): Homo sapiens (Human) 
2024-09-30 | PXD034237 | Pride
Ttll11 Wnt signaling Lc-ms Polyglutamylation Dvl3 Interactome 
ProteomicsChange of DVL3 interacting partners upon its polyglutamylation
Polyglutamylation is a reversible post-translational modification initially discovered on tubulin. In eukaryotes, polyglutamylation is catalyzed by enzymes from the tubulin tyrosine ligase-like (TTLL) family, which show substrate and reaction specificities that are so far mostly explored on tubulin....
ORGANISM(S): Homo sapiens (Human) 
2024-09-30 | PXD033548 | Pride
Ttll11 Wnt signaling Lc-ms Polyglutamylation Dvl3 Interactome 
TranscriptomicsPolyglutamylation of microtubules drives neuronal remodeling
Developmental remodeling shapes neural circuits via activity-dependent pruning of synapses and axons. The cytoskeleton is critical for this process, as microtubule loss via enzymatic severing is an early step of pruning across many circuits and species. However, how microtubule-severing enzymes, suc...
ORGANISM(S): Mus musculus 
2025-05-28 | GSE296782 | GEO
UnknownTubulin polyglutamylation differentially regulates microtubule-interacting proteins.
Not available
S-EPMC9975938 | biostudies-literature
UnknownReduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas.
Not available
S-EPMC4571340 | biostudies-literature
UnknownExcessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.
Not available
S-EPMC6276888 | biostudies-literature
UnknownDoublecortin restricts neuronal branching by regulating tubulin polyglutamylation.
Not available
S-EPMC11836384 | biostudies-literature
UnknownCarboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.
Not available
S-EPMC11574253 | biostudies-literature
UnknownNon-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation.
Not available
S-EPMC11619382 | biostudies-literature
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