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ProteomicsLC-MS/MS of HEK-293 inducibly expressing TDP-43 protein (WT and 3 non-functional mutants)
Aggregation of the RNA-binding protein TDP-43 is the key neuropathological feature of neurodegenerative diseases, including ALS and FTLD. TDP-43 is a ubiquitously expressed, nucleic acid-binding protein essential for human development. In physiological conditions, TDP-43 is predominantly nuclear, fo...
ORGANISM(S): Homo sapiens (Human) 
2023-08-31 | PXD041795 | Pride
Human Kidney Tdp-43 Lc-ms/ms 
ProteomicsSeeded aggregation of TDP-43 induces its loss of function
Neurodegeneration in ALS and FTD results from both gain of toxicity and loss of normal function of the RNA-binding protein TDP-43, but their mechanistic connection remains unclear. Increasing evidence suggests that TDP-43 aggregates act as self-templating seeds, propagating pathology through the cen...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD058981 | Pride
Dia Low input Tdp-43 Als Ftd Timstof 
ProteomicsSynaptic accumulation of FUS triggers early misregulation of synaptic RNAs in ALS-FUS mice
Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs, but its role at the synapse is poorly understood. Using super-resolution imaging we determined that the localization of ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-05 | PXD024075 | Pride
Mouse Als Cortex Label-free quantification Fus Synaptoneurosomes Neurodegeneration Orbitrap 
UnknownArrayed Genome-Wide Perturbation Screen Identifies Hnrnpk As Rate-Limiting for Prion Propagation
Not available
S-SCDT-10_15252-EMBJ_2022112338 | biostudies-other
UnknownThe ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis
Not available
S-SCDT-10_1038-S44321-024-00107-0 | biostudies-other
UnknownLAG3 is not expressed in human and murine neurons and does not modulate ?-synucleinopathies
Not available
S-SCDT-EMM-2021-14745 | biostudies-other
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