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TranscriptomicsCellular Transcriptional Responses to Merkel cell polyomavirus T antigens
Merkel cell polyomavirus (MCV) is clonally integrated in over 80% of Merkel cell carcinomas and mediates tumor development through the expression of viral oncoproteins large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T antigen locus that result ...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-68503 | biostudies-arrayexpress
TranscriptomicsJC polyomavirus whole genome sequencing at the single molecule level reveals emerging viral populations in Progressive Multifocal Leucoencephalopathy
JC polyomavirus (circular genome) contains two opposite coding regions separated by the regulator non-coding control region (NCCR). NCCR rearrangements and missense mutations in the viral capsid protein VP1 gene differentiate JCV prototype genomes recovered from PML lesions from archetype urine stra...
ORGANISM(S): JC polyomavirus 
2022-01-12 | E-MTAB-11077 | biostudies-arrayexpress
TranscriptomicsDiscovery of a Novel Human Polyomavirus in Acute Diarrheal Samples from Children
By unbiased deep sequencing, we identified a novel, highly divergent polyomavirus, provisionally named MX polyomavirus (MXPyV), in stool samples from children. From Mexico, 12 samples (out of 96) were positive for MxPyV by MXPyV-specific PCR. We used the ViroChip microarray and PCR to screen these 1...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-40008 | biostudies-arrayexpress
GenomicsJC polyomavirus
JC polyomavirus Targeted Locus (Loci)
PRJNA248428 | ENA
GenomicsJC polyomavirus
JC polyomavirus Targeted Locus (Loci)
PRJNA205610 | ENA
GenomicsWU Polyomavirus
WU Polyomavirus Genome sequencing and assembly
PRJNA663189 | ENA
GenomicsWU Polyomavirus
WU Polyomavirus Genome sequencing and assembly
PRJNA663191 | ENA
ProteomicsTemporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing
BK polyomavirus (BKPyV) is a small DNA virus that establishes a life-long persistent infection in the urinary tract of most people. BKPyV is known to cause severe morbidity in renal transplant recipients and can lead to graft rejection. The simple 5.2 kilobase pair dsDNA genome expresses just seven ...
ORGANISM(S): Homo sapiens (Human) BK polyomavirus MM 
2019-05-23 | PXD013940 | Pride
Quantitative proteomics  tandem mass tag  systems virology  polyomavirus  interferon  immune evasion  innate immunity  cell cycle 
TranscriptomicsClonal Immortalized Human Glial Cell Lines Support Varying Levels of JC Virus Infection due to Differences in Cellular Gene Expression
JC virus (JCV) is a ubiquitous human polyomavirus that causes the demyelinating disease Progressive Multifocal Leukoencephalopathy (PML). JCV replicates in limited cell types in culture, predominantly in human glial cells. Thus, productive JCV infection is an indicator of the host cell transcription...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-45639 | biostudies-arrayexpress
ProteomicsComprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles
JC polyomavirus (JCPyV) is the causative agent of progressive multifocal leukoencephalopathy (PML), a devastating demyelinating disease of the central nervous system that results in the widespread formation of lesions across the brain parenchyma. The virus is opportunistic and remains in a benign st...
ORGANISM(S): Homo sapiens (Human) JC polyomavirus 
2023-08-28 | PXD044144 | Pride
Pml Astrocytes Hipsc Model Jcpyv 
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