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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
TranscriptomicscaArray_cho-00156: Gene Expression in Ovarian Cancer Reflects Both Morphology and Biological Behavior
Biologically and clinically meaningful tumor classification schemes have long been sought. Some malignant epithelial neoplasms, such as those in the thyroid and endometrium, exhibit more than one pattern of differentiation, each associated with distinctive clinical features and treatments. In other ...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-68600 | biostudies-arrayexpress
ProteomicsProteomic analysis of human follicular fluid in poor ovarian responders during in vitro fertilization
Poor ovarian response (POR) observed in controlled ovarian stimulation (COS) is often observed during in vitro fertilization and embryo transfer (IVF-ET) cycles and is a major problem. A POR has been found to be related to several factors, including advanced age, high body mass index, and history of...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005436 | Pride
Multiple reaction monitoring Follicular fluid Biomarker Proteomics Poor ovarian response 
TranscriptomicsCHAC1 mRNA expression is a strong prognostic biomarker in breast and ovarian cancer
Extracellular, cancer-specific methylated DNA has been shown to be a prognostic marker when detected in serum or plasma. In this study we investigated the effect of treating cancer cells with differentially methylated CpG DNA. When breast cancer cell lines were treated with methylated CpG DNA, a con...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-22865 | biostudies-arrayexpress
TranscriptomicsOvarian Cancer Cell line Panel (OCCP): gene expression data.
Epithelial ovarian cancer is a very heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Rational therapeutic approaches need to account for interpatient and intratumoral heterogeneity in treatment design. Detailed characterization of in vitro models repr...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-53418 | biostudies-arrayexpress
TranscriptomicsClinical Relevance of Multidrug Resistance Gene Expression in Ovarian Serous Carcinoma Effusions
The presence of tumor cells in effusions within serosal cavities is a clinical manifestation of advanced-stage cancer and is generally associated with poor survival. Identifying molecular targets may help to design efficient treatments to eradicate these aggressive cancer cells and improve patient s...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-29702 | biostudies-arrayexpress
TranscriptomicsOvarian Tumor Samples: mixed reference of 106 pooled ovarian samples vs. individual patient ovarian sample
The goal of the study was to identify molecular subgroups that might predict clinical outcomes in serous epithelial ovarian cancer (EOC) patients. A second objective was to identify potential therapeutic targets for serous EOC based on improved understanding of the molecular diversity of the diseas...
ORGANISM(S): Homo sapiens 
2013-12-26 | E-GEOD-51088 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epithelial ovarian cancer cell lines treated with Carboplatin reveals carboplatin induced gene expression changes in vitro are prognostic of survival - time series
We performed a time-course microarray experiment to define the transcriptional response to carboplatin in vitro, and to correlate this with clinical outcome in epithelial ovarian cancer (EOC). RNA was isolated from carboplatin and control-treated 36M2 ovarian cancer cells at several time points, fol...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-13525 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of carcinoma-stem-like cells (CSC) extracted from a primary ovarian cancer cell line
A population of non-adherent cells with stem-like characteristics (OVA-BS4 spheres) has been isolated from a primary human epithelial ovarian cancer (EOC) cell line (OVA-BS4) under selective conditions. OVA-BS4 spheres were characterized for their pharmacological properties and their molecular profi...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-4799 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling in high-grade serous ovarian carcinoma
In this study, we performed miRNA profiles analysis of high-grade serous ovarian carcinoma compared to normal fallopian tube fimbria using microarray (Exiqon, Denmark) to evaluate their potential role in the pathogenesis of uterine leiomyoma. miRNA profiling analysis of the 10 samples including 5 h...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-61485 | biostudies-arrayexpress
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