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TranscriptomicsComparison of stimulatory and inhibitory dendritic cell subsets reveals new role of DC in granulomatous infection
Myeloid dendritic cells (DC) and macrophages play an important role in pathogen sensing and antimicrobial defense. Recently we demonstrated that infection of human DC with intracellular bacterium Listeria monocytogenes (L.monocytogenes) leads to the induction of the immunoinhibitory enzyme indoleami...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-9946 | biostudies-arrayexpress
TranscriptomicsCD40-activation of human B cells
Antibody-independent effector functions of B cells, such as antigen presentation and cytokine production, have been shown to play an important role in a variety of immune-mediated conditions such as autoimmune diseases, transplant rejection and graft-versus-host disease. Therapeutic strategies, whi...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-54017 | biostudies-arrayexpress
ProteomicsEffect of MSC and MSC-derived extracellular vesicles on human blood coagulation
Mesenchymal stem cells (MSC) have emerged as potent therapeutic tool for a number of pathologies, including immune ones. However, unwelcome effects of MSC on the blood coagulation were revealed in some cases, which require more in-depth analysis. In this study, we explored the trombotic properties o...
ORGANISM(S): Homo sapiens (Human) 
2019-03-26 | PXD012768 | Pride
Human Mesenchymal stem cells Vesicles 
ProteomicsTHE EFFECTS OF SPACE FLIGHT FACTORS ON THE HUMAN PLASMA PROTEOME, INCLUDING BOTH REAL SPACE MISSIONS AND GROUND-BASED MODEL EXPERIMENTS.
The aim of the study was to continue of the proteomic data accumulation on the effects of space flight factors on the human body, including ground-based model experiments. Blood plasma samples were collected from 5 healthy men included in the 21 days head-down bed rest experiment (HDBR) and 5 volun...
ORGANISM(S): Homo sapiens (Human) 
2019-07-04 | PXD013305 | Pride
Spaceflight Ground-base experiments Proteomics Mass-spectrometry Astronauts Dry immersion Head down bed rest Extreme conditions 
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