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TranscriptomicsThe Arabidopsis spaceflight transcriptome: a comparison of whole plants to discrete root, hypocotyl and shoot responses to the orbital environment
Arabidopsis thaliana was evaluated for its response to the spaceflight environment in three replicated experiments on the International Space Station. Two approaches were used; GFP reporter genes were used to collect gene expression data in real time within unique GFP imaging hardware, and plants we...
ORGANISM(S): Arabidopsis thaliana 
2013-10-04 | E-MTAB-1264 | biostudies-arrayexpress
TranscriptomicsTranscriptional and proteomic response of Pseudomonas aeruginosa PAO1 to spaceflight conditions involves Hfq regulation and reveals a role for oxygen
Characterization of bacterial behavior in the microgravity environment of spaceflight is of importance towards risk assessment and prevention of infectious disease during long-term missions. Further, this research field unveils new insights into connections between low fluid-shear regions encountere...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2011-06-28 | E-GEOD-22684 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the response of Arabidopsis cultivar Columbia etiolated seedlings and undifferentiated tissue culture cells to the spaceflight environment
We address a key baseline question of whether gene expression changes are induced by the orbital environment, and then we ask whether undifferentiated cells, cells presumably lacking the typical gravity response mechanisms, perceive spaceflight. Arabidopsis seedlings and undifferentiated cultured Ar...
ORGANISM(S): Arabidopsis thaliana 
2012-03-08 | E-MTAB-1009 | biostudies-arrayexpress
TranscriptomicsDrosophila melanogaster gene expression changes after spaceflight.
Gene expression levels were determined in 3rd instar and adult Drosophila melanogaster reared during spaceflight, to elucidate the genetic and molecular mechanisms underpinning the effects of microgravity on the immune system. The goal was to validate the Drosophila model for understanding alterati...
ORGANISM(S): Drosophila melanogaster 
2011-08-31 | E-GEOD-23880 | biostudies-arrayexpress
ProteomicsThe effects of spaceflight on the muscles of the murine shoulder
The study compared the protein composition of supraspinatus muscle from the spaceflight mice subjected to either the 13-day NASA STS-135 mission or the 30-day Bion-M1 mission and their corresponding ground control mice.
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD006764 | Pride
Mouse Proteomics Microgravity Shoulder muscle Spaceflight 
ProteomicsProteomic dataset of MECP2-deficient and wild-type human brain organoids under spaceflight and ground conditions
This dataset presents deep proteomic profiles of human brain organoids cultured aboard the International Space Station (ISS) and on Earth. We analyzed MECP2-deficient (Q83X) and isogenic wild-type control (WT83) organoids exposed to spaceflight and ground conditions for 30 days. Using LC-MS/MS on an...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD069807 | Pride
Astrocytes Proteomics Brain organoids L1 retrotransposition Mecp2 Microgravity Retrotransposons Neurodegeneration Senescence 
ProteomicsIntegrated proteomic and Metabolomic analysis to study the effects of spaceflight on Candida albicans
Background: Candida albicans is an opportunistic pathogenic yeast, which could become pathogenic in various stressful environmental factors including the spaceflight environment. In this study,we aim to explore the phenotypic changes and possible mechanisms of Candida albicans after exposure to spac...
ORGANISM(S): Candida Albicans 
2020-08-27 | PXD016983 |
TranscriptomicsCandida albicans response to spaceflight (NASA STS-115)
This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions. Microarray analysis revealed that C. albicans subjected to short-term spaceflight culture differentially...
ORGANISM(S): Candida albicans 
2013-11-01 | E-GEOD-50881 | biostudies-arrayexpress
ProteomicsEffect of spaceflight on the phenotype and proteome of Escherichia coli
BACKGROUND: Microbial safety has become a research hotspot with the development of manned space technology. Escherichia coli is a conditional pathogen that can cause infectious diseases. Therefore, it is necessary to study the influence of space environment on Escherichia coli. METHODS: Phenotypic e...
ORGANISM(S): Escherichia Coli 
2020-12-16 | PXD023158 |
UnknownNrf2 plays a critical role in the metabolic response during and after spaceflight.
Not available
S-EPMC8660801 | biostudies-literature
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