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TranscriptomicsTranscription profiling of human HeLa cells treated with major listerial toxin listeriolysin
Upon infection, pathogens reprogram host gene expression. In eukaryotic cells, genetic reprogramming is induced by the concerted activation/repression of transcription factors and various histone modifications that control DNA accessibility in chromatin. We report here that the bacterial pathogen, ...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1078 | biostudies-arrayexpress
ProteomicsBacterial pore-forming toxins remodel the host epithelial cell proteome
Bacterial pathogens use various strategies to interfere with host cell functions. Among these strategies, bacteria induce transcriptional changes, in order to modify the set of proteins synthetized by the host cell, or target pre-existing proteins by modulating their post-translational modifications...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD006900 | Pride
Listeria infection Pore-forming toxin Silac Listeriolysin o 
ProteomicsIdentification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins
Bacteroidales are abundant Gram-negative bacteria present in the gut microbiota of most animals, including humans, where they carry out vital functions for host health. To thrive in this competitive environment, Bacteroidales use sophisticated weapons to outmatch competitors. Among these, BSAPs (Bac...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) 
2025-11-29 | PXD062775 | Pride
Lc-msms Bacteroides fragilis Bsap receptor Co-purification Membrane fraction 
ProteomicsCells responding to bacterial pore-forming toxins release extracellular vesicles displaying similar proteomic content
The plasma membrane (PM) protects cells from extracellular threats and supports cellular homeostasis. Some pathogens produce pore-forming toxins (PFTs) that disrupt PM integrity by forming transmembrane pores. High PFT concentrations cause massive damage leading to cell death and facilitating infect...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD037166 | Pride
Calcium influx Shedding Extracellular vesicles Hela Listeriolysin o Label-free Pneumolysin Q exactive Pore-forming toxins Plasma membrane repair 
UnknownBacterial pore-forming toxins.
Not available
S-EPMC9558359 | biostudies-literature
UnknownRole of pore-forming toxins in neonatal sepsis.
Not available
S-EPMC3655490 | biostudies-literature
TranscriptomicsListeria monocytogenes induces T cell receptor unresponsiveness via its pore-forming toxin listeriolysin O
The success of many pathogens relies on their ability to circumvent the innate and adaptive immune defenses. How bacterial pathogens subvert host responses is not clear. Cholesterol-dependent cytolysins (CDCs) represent an expansive family of homologous pore-forming toxins produced by more than 20 G...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-19337 | biostudies-arrayexpress
ProteomicsBacterial pore-forming toxins remodel the host epithelial cell proteome
Bacterial pathogens use various strategies to interfere with host cell functions. Among these strategies, bacteria induce transcriptional changes, in order to modify the set of proteins synthetized by the host cell, or target pre-existing proteins by modulating their post-translational modifications...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD006996 | Pride
Listeria Infection Listeriolysin o 
UnknownMitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.
Not available
S-EPMC503732 | biostudies-literature
UnknownInhibition of Pore-Forming Proteins.
Not available
S-EPMC6784129 | biostudies-literature
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