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ProteomicsPositional proteomics reveals differences in N-terminal proteoform stability.
To understand the impact of alternative translation initiation on a proteome, we performed the first large-scale study of protein turnover rates in which we distinguish between N-terminal proteoforms pointing to translation initiation events. Using pulsed SILAC combined with N-terminal COFRADIC we m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083565 | MassIVE
ProteomicsQuantifying Positional Isomers (QPI) by top-down mass spectrometry
Proteomics has exposed a plethora of post-translational modifications, but demonstrating functional relevance requires new approaches. Top-down proteomics can characterize co-occurring modifications in terms of localization, abundance and hierarchy. Here, we present a top-down MS analysis workflow f...
ORGANISM(S): Homo sapiens (Human) 
2021-03-18 | PXD012084 | Pride
Top-down mass spectrometry Positional isomers Quantitation Phosphorylation 
TranscriptomicsPositional proteomics reveals differences in N-terminal proteoform stability
To understand the impact of alternative translation initiation on a proteome, we performed the first study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes. Overall, we monitored the stability of 1,941 human N-te...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-74279 | biostudies-arrayexpress
ProteomicsCLIPPER 2.0: Peptide level annotation and data analysis for positional proteomics
Positional proteomics methodologies have transformed protease research and have brought mass spectrometry (MS)-based degradomics studies to the forefront of protease characterization and system-wide interrogation of protease signaling. Considerable advancements in sensitivity and throughput of liqui...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD047261 | Pride
Lc-ms Post-translational modification Positional proteomics Computational proteomics Degradomics 
UnknownCLIPPER 2.0: Peptide-Level Annotation and Data Analysis for Positional Proteomics.
Not available
S-EPMC11192779 | biostudies-literature
TranscriptomicsPositional proteomics reveals differences in N-terminal proteoform stability
To understand the impact of alternative translation initiation on a proteome, we performed the first study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes. Overall, we monitored the stability of 1,941 human N-te...
ORGANISM(S): Homo sapiens 
2015-10-23 | GSE74279 | GEO
UnknownQuantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry.
Not available
S-EPMC8099777 | biostudies-literature
ProteomicsDual-Resolving of Positional and Geometric Isomerism of C=Cs via Bifunctional Visible-light-activated Photocycloaddition-Photoisomerization Reaction System
The biological functions of lipids largely depend on their chemicalspatial structures. The position and configuration of C=C bonds are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Her...
ORGANISM(S): Homo Sapiens Arabidopsis Thaliana 
2022-02-19 | PXD031819 |
GenomicsHomo sapiens
Positional proteomics reveals differences in N-terminal proteoform stability
PRJNA299254 | ENA
UnknownPositional proteomics reveals differences in N-terminal proteoform stability.
Not available
S-EPMC4770386 | biostudies-literature
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