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UnknownTransformation of Pro-Leu-Gly-NH2 peptidomimetic positive allosteric modulators of the dopamine D2 receptor into negative modulators.
Not available
S-EPMC3389495 | biostudies-literature
UnknownFunctional insight into development of positive allosteric modulators of AMPA receptors.
Not available
S-EPMC4107126 | biostudies-literature
UnknownBivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series.
Not available
S-EPMC6837176 | biostudies-literature
UnknownProposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.
Not available
S-EPMC4950826 | biostudies-literature
UnknownPositive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies.
Not available
S-EPMC9553105 | biostudies-literature
UnknownEnantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor.
Not available
S-EPMC8270344 | biostudies-literature
UnknownIdentification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.
Not available
S-EPMC4025801 | biostudies-literature
UnknownDiscovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.
Not available
S-EPMC4007895 | biostudies-literature
UnknownPositive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Not available
S-EPMC60883 | biostudies-literature
ProteomicsLow intrinsic agonism and balanced pathway modulation distinguish an M1 muscarinic receptor positive allosteric modulator lacking cholinergic adverse effects
Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (mAChR) have progressed into clinical trials for cognitive disorders, such as Alzheimer’s disease and schizophrenia. This work provides a mechanistic framework for differentiating M1 PAM pharmacology beyond intrinsic a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD074843 | Pride
Signalling pathways Schizophrenia Cognition Alzheimer's disease M1 muscarinic acetylcholine receptors Allosteric modulation Biased allosterism 
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