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Diphthamide, a post-translationally modified histidine residue of eukaryotic TRANSLATION ELONGATION FACTOR2 (eEF2), is the human host cell-sensitizing target of diphtheria toxin. Diphthamide biosynthesis depends on the 4Fe-4S-cluster protein Dph1 catalyzing the first committed step, as well as Dph2 ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-11 | PXD034873 | Pride
The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their target genes using genome-wide location analysis in human embryonic fibroblasts. We find that Polyco...
ORGANISM(S): Homo sapiens 
Recombinant antibodies to histone post-translational modifications (PTMs), with their essentially infinite renewability, could fundamentally eliminate a major source of low reproducibility in epigenetics research. Here, we report new recombinant antibodies to trimethylated Lys4 and Lys9, respectivel...
ORGANISM(S): Homo sapiens 
This a model from the article: Data assimilation constrains new connections and components in a complex, eukaryotic circadian clock model. Pokhilko A, Hodge SK, Stratford K, Knox K, Edwards KD, Thomson AW, Mizuno T, Millar AJ. Mol Syst Biol.2010 Sep 21;6:416. 2...
2024-09-02 | BIOMD0000000273 | BioModels
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic causes a major health burden. Garlic organosulfur compounds, such as the diallyl thiosulfinate allicin exert strong antimicrobial activity against various respiratory pathogens. Here, we investigated the antiviral activity of ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-30 | PXD024375 | Pride
An EST database from immune tissues was used to design the first high density turbot (Scophthalmus maximus) oligo-microarray with the aim of identifying candidate genes for tolerance to pathogens. Specific oligonucleotides (60mers) were successfully designed for 2716 out of 3482 unique sequences of ...
ORGANISM(S): Psetta maxima 
The protozoan Giardia lamblia is a unique biological model to investigate minimal cellular mechanisms because it is an early‐diverged eukaryote that has undergone reductive evolution and has minimized or lost organelles such as mitochondria, peroxisomes, the endo-lysosomal system and a Golgi apparat...
ORGANISM(S): Giardia lamblia ATCC 50803 
2014-03-11 | PXD000694 | Pride
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