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ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-27 | MSV000084240 | MassIVE
ProteomicsPost-synaptic density proteomic analysis of the Taok2 KO mouse cortex
Idententification of differentially expressed proteins in the post-synaptic density fraction of Taok2 KO mouse cortices
ORGANISM(S): Mus musculus (Mouse) 
2022-11-11 | PXD036937 | Pride
Lc-ms/ms Shotgun proteomics Psd 
ProteomicsTargeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Individuals with Alzheimer Disease with psychotic symptoms (AD+P) experience more rapid cognitive and functional decline, and have reduced indices of synaptic integrity, relative to those without psychosis (AD-P). We hypothesized the postsynaptic density (PSD) proteome is altered in AD+P relative to...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042026 | Pride
Alzheimer’s disease  psychosis  post-synaptic density  proteomics: systems pharmacology 
ProteomicsCorrelation profiling of synaptic sub-fraction proteomes of the mouse brain hippocampus, cortex and cerebellum
Synaptic transmission forms the main mode of signaling and information integration in the nervous system. Here, we identified and quantified proteins from three brain regions and five biochemical synapse sub-fractions. We identified around 4500 proteins in total, of which about 2000 proteins each we...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-25 | PXD005634 | Pride
Post synaptic density Synapse Proteomics Correlation profiling 
ProteomicsLoss of the E3 ubiquitin ligase Trim9 or Trim67 alters the post-synaptic density proteome
During development, neurons undergo expansive growth and shape change to achieve their mature morphology and physiological function. As cellular remodeling occurs, proteins are synthesized, transported, degraded, and recycled. As such, protein levels and localization are tightly regulated. E3 ubiqui...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD048045 | Pride
Synapse  post-synaptic density  trim9  trim67  e3 ubiquitin ligase 
ProteomicsSearch for synaptic biomarkers of Alzheimer’s disease
As synapse degeneration is an early event in Alzheimer’s disease (AD) pathophysiology, a biofluid marker of synapse loss in living patients could be a surrogate marker of disease prognosis and therefore would be an excellent addition to the AD biomarker arsenal. With direct access to the brain inter...
ORGANISM(S): Homo Sapiens 
2019-01-10 | PXD012138 | panorama
ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-05 | PXD031129 | JPOST Repository
UnknownThe effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome.
Not available
S-EPMC3192943 | biostudies-literature
UnknownPost-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth.
Not available
S-EPMC12546983 | biostudies-literature
UnknownLoss of the E3 ubiquitin ligase TRIM67 alters the post-synaptic density proteome.
Not available
S-EPMC10802379 | biostudies-literature
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