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Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 mth following their acute phase of infection to comprehensively profile and as...

2024-02-23 | MTBLS7337 | MetaboLights
We performed longitudinal plasma proteomics analysis and determined absolute protein levels in a Canadian cohort (n=74) at admission day to hospital for acute COVID-19 and at 3 and 6 months after diagnosis of acute COVID-19. We measured plasma protein on a triple quadrupole mass spectrometer operate...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041762 | Pride
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the large-scale mass-spectrometric quantification of glycopeptides in pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-29 | MSV000089567 | MassIVE
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk-factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2...
ORGANISM(S): Homo sapiens 
Vitamin D (VD) has a coordinated immune function. Decreased VD levels are closely related to the occurrence of post-COVID-19 Conditions (PCC), but the specific mechanism is still unclear. Methods: We collected 50 PCC patient serum samples and divided them into three groups by different VD levels: VD...
ORGANISM(S): Homo Sapiens 
2025-11-27 | PXD059686 |
This study presents a longitudinal multi-omics analysis of COVID-19 convalescents with respiratory sequelae, spanning 6–36 months post-infection. The integrating proteomic and metabolomic profiling uncovers persistent molecular alterations, impaired diffusing capacity for carbon monoxide, and propos...
ORGANISM(S): Homo Sapiens 
2025-02-23 | PXD061113 |
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