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TranscriptomicsHeLa cell mitochondrial microRNAs
MicroRNAs (miRNAs) are small non-coding RNAs that associate with Argonaute 2 protein to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in other cellular compartments. Mitochondria harbour th...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-24761 | biostudies-arrayexpress
GenomicsPDK1 coordinates mitochondrial dynamics and mitophagy to ensure mitochondrial maturation in post-natal cardiomyocytes
PDK1 coordinates mitochondrial dynamics and mitophagy to ensure mitochondrial maturation in post-natal cardiomyocytes
PRJNA888132 | ENA
TranscriptomicsPDK1 coordinates mitochondrial dynamics and mitophagy to ensure mitochondrial maturation in post-natal cardiomyocytes
During early post-natal stage, cardiomyocytes undergo dramatic structural, metabolic, electrophysiological and cell cycle alterations towards maturation. Among them, the metabolic shift from carbohydrates to fatty acids metabolism is achieved along with mitochondrial biogenesis, dynamic switch and m...
ORGANISM(S): Mus musculus 
2023-08-01 | GSE215056 | GEO
ProteomicsReactive Metabolite-induced Protein Glutathionylation Mechanistically Accounts for Acetaminophen Hepatotoxicity
Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induces widespread protein glutathionylation in a time-, dose- and bioactivation-dependent manner in Hepa...
ORGANISM(S): Homo Sapiens (human) 
2018-09-20 | PXD009986 | JPOST Repository
ProteomicsACONITASE 3 is post-translationally controlled in response to mitochondrial stress signals in Arabidopsis
Mitochondria are tightly embedded within metabolic and regulatory networks that optimize plant performance upon environmental challenges. The best-known mitochondrial retrograde signaling pathway involves stress-induced activation of the transcription factor ANAC017, which mediates the onset of prot...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-06-08 | PXD024316 | Pride
Phosphorylation Post-translational regulation Aconitase Mitochondrial dysfunction response 
ClinicalThe impact of frailty, activity levels and mitochondrial efficiency on post operative outcomes in older patients undergoing abdominal surgery
Interventions: This will be an observational study of older patients undergoing elective colorectal surgery. Patients will be recruited at least two weeks and not more than six months prior to surgery. Markers of frailty will be assessed preoperatively using three different measures. 1. An edmont...
2466459 | ecrin-mdr-crc
ProteomicsTeleost spermatozoa can conduct de novo cytoplasmic and mitochondrial translation during post-testicular maturation
Translational silence of spermatozoa has long been considered the norm in animals. However, studies in mammals have shown that the mitochondrial ribosomal machinery is selectively activated during capacitation in the female reproductive tract, while cytoplasmic ribosomes remain inactive. Here, using...
ORGANISM(S): Sparus aurata 
2025-05-07 | PXD056370 | Pride
Proteomics Efferent duct Sperm motility Polysomes Fish Lc-ms/ms 
GenomicsEnhanced pre-pubertal nutrition upregulates mitochondrial function in the testes and sperm of post-pubertal Holstein bulls
Enhanced pre-pubertal nutrition upregulates mitochondrial function in the testes and sperm of post-pubertal Holstein bulls
PRJNA566324 | ENA
UnknownPost-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology.
Not available
S-EPMC11489592 | biostudies-literature
ProteomicsMitochondrial ribosomal protein L12 (MRPL12) post-translational modifications
Analysis of post-translational modifications on mitochondrial protein L12 (MRPL12). MRPL12 was overexpressed in HeLa or HEK293 cells, immunoprecipitated, and subject to bottom-up proteomic analysis on an Agilent 6545 LC-qTOF.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-08 | MSV000093335 | MassIVE
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