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In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homologs of these proteins (BAP1 and ASXL1/2/3, respectively), are frequently mutated in various cancer typ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-28 | PXD011808 | Pride
Evaluate R-Loop accumulation in different cell line in response to PARP inhibitor treatment
ORGANISM(S): Homo sapiens 
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