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TranscriptomicsIn-Vitro Cell Adhesion Assay
Cigarette smoke (CS) has been reported to affect the adhesion of monocytes to endothelial cells, a critical step in atherogenesis. Using an in vitro adhesion assay together with innovative computational systems biology approaches to analyze omics data, our study aimed at investigating CS-induced mec...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-MTAB-3644 | biostudies-arrayexpress
TranscriptomicsIn-Vitro Cell Adhesion Assay
Alterations of endothelial adhesive properties by cigarette smoke (CS) can progressively favor the development of atherosclerosis which may cause cardiovascular disorders. Modified risk tobacco products (MRTPs) are tobacco products scientifically validated to reduce smoking-related health risks. A s...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-MTAB-3923 | biostudies-arrayexpress
TranscriptomicsIn-Vitro Cell Adhesion Assay
The adhesion of monocytic cells to the M-^SdysfunctionalM-^T endothelium constitutes a critical step in the initiation of atherosclerotic plaque formation. Cigarette smoke (CS) has been shown to contribute to the monocyte-endothelial adhesion process. Yet, the complex mechanisms underlying this even...
ORGANISM(S): Homo sapiens 
2014-04-24 | E-MTAB-1173 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms of cigarette smoke-induced lung emphysema
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disorder primarily induced by cigarette smoking, and characterized by persistent airflow limitation. The mouse represents an important model for studying COPD pathologies such as lung emphysema. In this respect, a number of mechanis...
ORGANISM(S): Mus musculus 
2014-11-28 | E-MTAB-2756 | biostudies-arrayexpress
TranscriptomicsIn vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells.
Cigarette smoke causes diseases such as cardiovascular disorders. Heating tobacco, instead of burning, reduces consistently the amount of toxic compounds and may exert a reduced impact on cardiovascular health compared to cigarettes. Aqueous extract from the aerosol of a potential modified risk toba...
ORGANISM(S): Homo sapiens 
2018-08-09 | E-MTAB-6721 | biostudies-arrayexpress
TranscriptomicsMulti-layer omics dataset for cross-species translational systems biology
Inferring in humans biological responses to external cues such as drugs, chemicals, viruses and hormones, is an essential question in biomedicine and cannot be easily studied in humans. Thus, biomedical research has continuously relied on animal models for studying the impact of these compounds and ...
ORGANISM(S): Rattus norvegicus 
2014-06-10 | E-MTAB-2091 | biostudies-arrayexpress
TranscriptomicsCOPD progression in C57l/6 mice in response to chronic exposure (up to 7 months) to conventional cigarette smoke or a prototype modified risk tobacco product (pMRTP) and the impact of cessation or switching to pMRTP after initial exposure to conventional cigarette smoke
Smoking of combustible cigarettes has a major impact on human health, so the tobacco industry is developing modified risk tobacco products (MRTP) to reduce this health risk. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the potent...
ORGANISM(S): Mus musculus 
2017-08-05 | E-MTAB-5281 | biostudies-arrayexpress
TranscriptomicsEffect of rimonabant on gene expression of visceral and subcutaneous adipose tissues: high fat diet
Mice were fed for 6 months with a normal chow (NC) or a high fat diet (HFD). After 6 months of diet, high fat fed mice with Low, Medium and High body weight, but with similar glucose intolerance, were selected. These selected mice as well as NC mice were then treated with Rimonabant or Vehicle for 1...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-11790 | biostudies-arrayexpress
TranscriptomicsIdentification of gene expression signature for cigarette smoke exposure response--from man to mouse.
Gene expression profiling data can be used in toxicology to assess both the level and impact of toxicant exposure, aligned with a vision of 21st century toxicology. Here, we present a whole blood-derived gene signature that can distinguish current smokers from either nonsmokers or former smokers wit...
ORGANISM(S): Homo sapiens 
2017-08-05 | E-MTAB-5279 | biostudies-arrayexpress
TranscriptomicsIdentification of gene expression signature for cigarette smoke exposure response--from man to mouse.
Gene expression profiling data can be used in toxicology to assess both the level and impact of toxicant exposure, aligned with a vision of 21st century toxicology. Here, we present a whole blood-derived gene signature that can distinguish current smokers from either nonsmokers or former smokers wit...
ORGANISM(S): Homo sapiens 
2017-08-05 | E-MTAB-5278 | biostudies-arrayexpress
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