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ProteomicsSelective Inhibition of MTHFD1/2 in T Cells from Patients with Rheumatoid Arthritis
Ex vivo T cell treatment Immunomagnetic negative isolation was used to obtain untouched human T cells from previously frozen PBMC samples of treatment-naïve (n=6) and MTX-IR (n=3) RA patients (Table S1). The isolated T cells were then cultured and stimulated in a 96-well round-bottom plates for susp...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PXD061849 | Pride
Proteomics Methotrexate Selective mthfd1/2 inhibitor T cells Rheumatoid arthritis 
TranscriptomicsGene expression by antigen activated OT-I T cells in vivo in the presence and absence of IL-2
Much is known concerning the cellular and molecular basis for CD8+ T memory immune responses. Nevertheless, conditions that selectively support memory generation have remained elusive. Here we show that an immunization regimen that delivers TCR signals through a defined antigenic peptide, inflammato...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39110 | biostudies-arrayexpress
TranscriptomicsDiagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
Cutaneous T-cell lymphomas (CTCL) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult due to a clinical and histological resemblance to benign inflammatory skin diseases. To address if microRNA (miRNA) profiling can discriminate CTCL from benig...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31408 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44266 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42424 | biostudies-arrayexpress
TranscriptomicsHelicobacter pylori induce miR-155 in T cells in a cAMP-Foxp3 dependant manner
The human pathogen Helicobacter pylori (Hp) colonizes the gastric epithelium as a unique niche in the stomach. Infections commonly occur in childhood and persist lifelong, leading in some cases to adenocarcinoma and MALT lymphoma. Several studies define mammalian microRNAs as key regulators of the i...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-18616 | biostudies-arrayexpress
ProteomicsProtein Interactome of U2AF2 during T cell activation
T cell activation leads to dramatic changes in cellular phenotype. We used activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show that U2AF2 binds the majority of transcripts that are...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD001843 | Pride
Rip mass spectrometry U2af Cd4 t cells Rna-binding proteins 
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42423 | biostudies-arrayexpress
ProteomicsFoxp3 positive and negative cell comparison
Regulatory T cells have been shown to adopt a catabolic metabolic programme with increased capacity for fatty acid oxidation fuelled oxidative phosphorylation (OXPHOS). The role of Foxp3 in this metabolic shift is poorly understood. Here we show that Foxp3 was sufficient to induce a significant incr...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-15 | PXD001789 | Pride
Mouse t cells 
TranscriptomicsExpression profile of microRNAs in human follicular lymphoma (FL), reactive lymph nodes (rLN) and pure T cells
MicroRNAs expression profile was acquired in 26 frozen FLs, 12 frozen rLNs, and in 2 CD4+ and 2 CD8+ pure T cell samples. The data were used to identify microRNAs differentially expressed between FLs of grade 1, 2, 3a and 3b and rLNs and between FLs and pure T cells.
ORGANISM(S): Homo sapiens 
2017-06-29 | E-MTAB-5844 | biostudies-arrayexpress
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