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MetabolomicsAn early-life microbiota metabolite protects against obesity via intestinal PPAR-gamma
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ORGANISM(S): Mus musculus 
ST002186 | MetabolomicsWorkbench
MetabolomicsMetabolomics dataset of PPAR-pan treated rat liver (eicosanoid assay)

This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript “PPAR-pan Activation Induces Hepatic Oxidative Stress and Lipidomic Re...

2016-05-13 | MTBLS278 | MetaboLights
MetabolomicsMetabolomics dataset of PPAR-pan treated rat liver (acyl-carnitine and aqueous metabolite assays)

This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript “PPAR-pan Activation Induces Hepatic Oxidative Stress and Lipidomic Re...

2016-05-13 | MTBLS303 | MetaboLights
TranscriptomicsThe immunoregulatory effect of macrophage-specific PPAR gamma deficiency on experimental inflammatory bowel disease
Inflammatory bowel disease (IBD) is a condition characterized by severe intestinal inflammation and immune cell activation. The severity of the disease can be mitigated by compounds which activate peroxisome proliferator-activated receptor gamma (PPAR gamma), a receptor present widely in tissues in...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-23421 | biostudies-arrayexpress
MetabolomicsJiawei Shoutai Pill Promotes Embryo Implantation via PPAR Signaling and Endometrial Microbiota Remodeling: An Integrative Multi-Omics Study
Background: Recurrent implantation failure (RIF) remains a major barrier to successful assisted reproductive technology, given the lack of effective, mechanism-informed interventions to enhance endometrial receptivity. Jiawei Shoutai Wan (pills) (JWSTW), a modified formulation of the classic Shoutai...
2026-03-31 | MTBLS14199 | MetaboLights
TranscriptomicsImmunoregulatory actions of epithelial cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20621 | biostudies-arrayexpress
TranscriptomicsImmunoregulatory actions of T cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20523 | biostudies-arrayexpress
TranscriptomicsExpression data from liver, PFC and amygdala of mice treated with PPAR agonists
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists have demonstrated therapeutic properties for several brain disorders, including alcohol depen...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-67796 | biostudies-arrayexpress
TranscriptomicsInterference with PPAR gamma signaling in mesenteric artery
Pharmacological activation of the transcription factor PPAR gamma lowers blood pressure and improves glucose tolerance in humans. In contrast, naturally occurring mutations (e.g., P467L, V290M) in the ligand binding domain of PPAR gamma in humans leads to severe insulin resistance and early-onset h...
ORGANISM(S): Mus musculus 
2012-09-24 | E-GEOD-36482 | biostudies-arrayexpress
TranscriptomicsChIP-chip of BMP2 or control treated human pulmonary artery endothelial cells with anti-beta-catenin or anti-ppar-gamma antibodies on promoter regions
Reduced bone morphogenetic protein receptor (BMPR)2 expression in patients with pulmonary arterial (PA) hypertension (PAH), can impair PA endothelial cell (EC) function. We now characterize, in human PAECs, a novel BMPR2-mediated transcriptionally active complex between peroxisome proliferator-activ...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-29489 | biostudies-arrayexpress
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