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ProteomicsTranslation rescue by targeting Ppp1r15a upstream open reading frame in vivo
The eIF2 initiation complex is central to maintaining a functional translation machinery. Extreme stress such as life-threatening sepsis exposes vulnerabilities in this tightly regulated system, resulting in an imbalance between the opposing actions of kinases and phosphatases on the main regulatory...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-09-28 | PXD030889 | Pride
Lcmsmsi Phoshporylation Ppp1r15a Uorf Kidney Eif2 initation complex Translation 
GenomicsTranslation rescue by targeting Ppp1r15a upstream open reading frame in vivo
Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo
PRJNA790822 | ENA
UnknownInhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis.
Not available
S-EPMC10943029 | biostudies-literature
GenomicsTurnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
PRJNA1086870 | ENA
TranscriptomicsTranslation rescue by targeting Ppp1r15a upstream open reading frame in vivo
The eIF2 initiation complex is central to maintaining a functional translation machinery. Extreme stress such as life-threatening sepsis exposes vulnerabilities in this tightly regulated system, resulting in an imbalance between the opposing actions of kinases and phosphatases on the main regulatory...
ORGANISM(S): Mus musculus Homo sapiens 
2021-12-22 | GSE191262 | GEO
UnknownSensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Not available
S-EPMC8566588 | biostudies-literature
UnknownPPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma.
Not available
S-EPMC11179254 | biostudies-literature
UnknownPPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
Not available
S-EPMC5429092 | biostudies-literature
UnknownInactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.
Not available
S-EPMC6393541 | biostudies-literature
TranscriptomicsTurnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation of Growth Arrest and DNA Damage inducible 34 (GADD34), a s...
ORGANISM(S): Homo sapiens 
2024-03-19 | GSE261399 | GEO
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