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ProteomicsS-adenosylhomocysteine hydrolase participates in DNA methylation inheritance
DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for mammalian development and maintenance of DNA methylation following DNA replication in cells. The DNA methylation process generates S-adenosyl-L-homocysteine, a strong inhibitor of DNMT1. Here we report that S-adenosylhomocysteine hydrolas...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD006476 | Pride
Dnmt1 Sahh Cell cycle 
ProteomicsMicrotubules methylation LC-MSMS
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood. Post-translational modifications of tubulin are proposed to regulate...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2020-02-28 | PXD014257 | Pride
Human Monomethylation Tubulin 
TranscriptomicsSmall RNA mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation
Mammalian cells contain copious amounts of RNA including both coding and non-coding RNA (ncRNA). Generally the ncRNAs function to regulate gene expression at the transcriptional and post-transcriptional level. Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, DNA methylati...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-68027 | biostudies-arrayexpress
GenomicsHigh-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells
We describe the use of a novel DNA modification-dependent restriction endonuclease AbaSI coupled with sequencing (Aba-seq) to map high-resolution hydroxymethylome of mouse E14 embryonic stem cells. The specificity of AbaSI enables sensitive detection of 5hmC at low occupancy regions. Bioinformatic a...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42898 | biostudies-arrayexpress
GenomicsConservation and divergence of methylation patterning in plants and animals
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. While DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNA methylation appear to vary drastically among different organisms. Here, we used shotgun genomic bisulfite ...
ORGANISM(S): Ciona intestinalis 
2010-04-09 | E-GEOD-21152 | biostudies-arrayexpress
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