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MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis (FIA-MS) (C.saccharolyticum;E.coli;L.plantarum;L.lactis;S.salivarius assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1791 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1792 | MetaboLights
ProteomicsNovel Events, Gene Model Correction of Mycobacterium Avium by Proteogenomic Analysis
Mycobacterium avium is one of the prominent disease causing bacteria in humans. It causes lymphadenitis, chronic pulmonary and extrapulmonary and disseminated infections in adults, children and immunocompromised humans. M. avium has ~4,500 predicted gene models, out of which not all are identified a...
ORGANISM(S): Mycobacterium avium 104 
2023-03-17 | PXD032067 | Pride
Dia Mycobacterium avium Proteogenomics Variant calling Dda Lc-ms/ms 
ProteomicsIntegrated multi-omic analysis of M. tuberculosis H37Ra redefines virulence attributes
M. tuberculosis H37Ra, an avirulent tubercle bacillus, is a commonly used model to investigate virulence attenuation in M. tuberculosis. Comparative high-throughput studies have earlier correlated its avirulence to the presence of specific mutations or absence of certain proteins. However, a recent ...
ORGANISM(S): Mycobacterium tuberculosis H37Ra 
2018-10-22 | PXD008555 | Pride
Genome annotation Tuberculosis Virulence attenuation Orbitrap Next-generation sequencing 
ProteomicsA Comparative Proteomic Analysis of Whey Protein from Early, Mid and Late Lactation Stages of Indian Indigenous Breed, MalnadGidda (Bosindicus)
Different lactation stages have marked influence on milk yield, milk constituents and nourishment of the neonates. However, the differential gene expression during different lactation stages in Bosindicus has not been investigated so far. In this study, we carried out high-resolution mass spectromet...
ORGANISM(S): Bos indicus 
2018-02-16 | PXD007655 | Pride
Ultracentrifugation Tmt labeling Isoelectric precipitation Brplc Biomarker 
ProteomicsExploring molecular dynamics indicators associated with reproductive performance of Bos indicus cattle in plasma samples through data-independent acquisition mass spectrometry
Aim of the study was to profile the blood plasma proteome of healthy Bos indicus cattle and use it as a baseline against which to compare different conditions in Bos indicus cattle, such as disease, reproduction associated proteins and pregnancy specific proteins etc. Data-independent acquisition (D...
ORGANISM(S): Bos taurus (Bovine) 
2024-07-15 | PXD034103 | Pride
Lc-ms/ms-dia Bos indicus Quantitative proteomics Plasma Animal reproduction Diary research 
ProteomicsReanalysis of Data-dependent acquisition based proteomic datasets of Mycobacterium avium subsp. paratuberculosis, Mycobacterium marinum and Mycobacterium vaccae
Detection of species-specific proteotypic peptides for accurate and easy characterization of infectious non-tuberculous mycobacteria such as Mycobacterium avium subsp. paratuberculosis, Mycobacterium marinum and Mycobacterium vaccae is essential. Therefore, we carried out reanalysis of publicly avai...
ORGANISM(S): Acyrthosiphon pisum (Pea aphid) 
2024-03-07 | PXD045965 | Pride
M. marinum M.vaccae Proteomics Non-tuberculous mycobacteria M. avium Lc-ms/ms 
ProteomicsReanalysis of Data-dependent acquisition based proteomic datasets of Mycobacterium abscessus
Detection of species-specific proteotypic peptides for accurate and easy characterization of infectious non-tuberculous mycobacteria such as Mycobacterium abscessus is essential. Therefore, we carried out reanalysis of publicly available M. abscessus proteomic dataset MSV000085363, PXD015680 and PXD...
ORGANISM(S): Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) 
2024-03-07 | PXD045930 | Pride
M. abscessus Proteomics Non-tuberculous mycobacteria Lc-ms/ms 
ProteomicsData-dependent acquisition based proteomic analysis of Mycobacterium kansasii ATCC 12478
Detection of species-specific proteotypic peptides for accurate and easy characterization of infectious non-tuberculous mycobacteria such as Mycobacterium kansasii is essential. Therefore, we carried out an in-depth global proteomic experiment using M. kansasii ATCC 12478 strain followed by proteome...
ORGANISM(S): Mycobacterium kansasii ATCC 12478 
2024-03-07 | PXD040523 | Pride
Mycobacterium kansasii Non-tuberculous mycobacteria Dda Lc-ms/ms 
ProteomicsData-dependent acquisition based proteomic analysis of Mycobacterium abscessus ATCC 19977
Detection of species-specific proteotypic peptides for accurate and easy characterization of infectious non-tuberculous mycobacteria such as Mycobacterium abscessus is essential. Therefore, we carried out an in-depth global proteomic experiment using M. abscessus ATCC 19977 strain followed by proteo...
ORGANISM(S): Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) Bacteria 
2024-03-07 | PXD040615 | Pride
Mycobacterium abscessus Non-tuberculous mycobacteria Dda Lc-ms/ms 
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