Selenium-dependent glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis and prevents unrestrained (phospho)lipid peroxidation by directly reducing phospholipid hydroperoxides (PLOOH) to their corresponding alcohols. However, it remains unclear whether other phospholipid peroxidases can als...
Whole protein mass spectrometry analysis of PRDX6 after reacting with selenium compounds, including sodium selenide (Na2Se), sodium selenite (Na2SeO3) and L-Selenocystine.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606)
This project describes the mechanism by wich PRDX6 affects migration and invasiveness in hepatocarcinoma cells. SNU475 (mesenchymal) hepatocarcinoma cell line knockout for PRDX6 showed a marked increase in ROS and lipid peroxidation, mytochondrial dysfunction, metabolic reprogramming, altered cytosk...
This dataset comprises RNA sequencing data generated from A223 squamous cell carcinoma cells with stable knockdown of PRDX6 or parental control, treated with either DMSO or 100 nM largazole (a class I histone deacetylase inhibitor) for 18 hours. The study investigates the role of PRDX6 in modulating...
Background: Retinitis pigmentosa is a polygenic genetic disease for which night blindness and progressive visual field shrinkage are the primary clinical manifestations. The pathogenesis of retinitis pigmentosa involves pathological changes in photoreceptor and retinal pigment epithelium (RPE) cells...
