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GenomicsSmall molecule RBI2 disrupts ribosome biogenesis through pre-rRNA depletion
Small molecule RBI2 disrupts ribosome biogenesis through pre-rRNA depletion
PRJNA778093 | ENA
ProteomicsCms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release Table S2
Ribosome synthesis begins in the nucleolus with 90S pre-ribosome construction, but little is known about how the many different snoRNAs that modify the pre-rRNA are timely guided to their target sites. Here, we report a role for Cms1 in such a process. Initially, we discover CMS1 as null suppressor ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD037619 | Pride
Ribosome biogenesis 90s pre-ribosome Snorna Cms1 
ProteomicsCms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release - table s1 corrected
Ribosome synthesis begins in the nucleolus with 90S pre-ribosome construction, but little is known about how the many different snoRNAs that modify the pre-rRNA are timely guided to their target sites. Here, we report a role for Cms1 in such a process. Initially, we discover CMS1 as null suppressor ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD037562 | Pride
Ribosome biogenesis 90s pre-ribosome Snorna Cms1 
ProteomicsThe novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation
The formation of new ribosomes is tightly coordinated with cell growth and proliferation. In eukaryotes, the correct assembly of all ribosomal proteins and RNAs involves an intricate cascade of maturation and rearrangement steps across three cellular compartments: the nucleolus, nucleoplasm, and cyt...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD046691 | Pride
Yeast 60s Ribosome biogenesis Lc-msms 
ProteomicsPre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
Budding yeast Tsr1 is an essential ribosome biogenesis factor that is required for cytoplasmic steps in 40S subunit maturation. S. cerevisiae Tsr1 was expressed as an N-terminal GST fusion protein in E. coli. A mutant Tsr1ΔNΔloop was generated in which residues 410 to 476 of Tsr1 were replaced with ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-08 | PXD004074 | Pride
Pre-40s ribosome biogenesis Protein structure Cross-linking/mass spectrometry 
TranscriptomicsRunx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67609 | biostudies-arrayexpress
UnknownSmall Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion.
Not available
S-EPMC10340317 | biostudies-literature
TranscriptomicsSmall molecule RBI2 disrupts ribosome biogenesis through pre-rRNA depletion
In all domains of life, the rate of protein synthesis is directly linked to the rates of cell growth and proliferation. Consequently, highly proliferative cancer cells are especially sensitive to perturbations in ribosome biogenesis. While ribosome synthesis and cancer have a well-established relati...
ORGANISM(S): Homo sapiens 
2021-11-08 | GSE188262 | GEO
UnknownAnalysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes.
Not available
S-EPMC2875017 | biostudies-literature
TranscriptomicsCircular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome ...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-65392 | biostudies-arrayexpress
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