Preclinical alzheimer's disease

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Laboratory for Neuropathology, Department of Imaging and Pathology, KU Leuven (University of Leuven), Leuven, Belgium;Leuven Brain Institute (LBI), KU Leuven (University of Leuven), Leuven, Belgium;Department of Imaging & Pathology, UZ Leuven (University Hospital Leuven), Leuven, Belgium. (1)
Max-Planck-Institute of Biochemistry (1)
Roskamp Institute, Neurodegenerative Disease and Proteomics Lab, Sarasota, FL (1)
UPF/CRG Proteomics Unit (1)
University of Rhode Island (1)

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Plasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults

Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...

2014-03-09 | MTBLS72 | MetaboLights

Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain

Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in four types of Alzheimer's disease (AD) mouse models and human AD postmortem brains. We identified commonly changed phosphoproteins in multiple models and also determined phosphoproteins related to initiation of Ab...

ORGANISM(S): Mus musculus (Mouse)

2014-09-10 | PXD001292 | Pride