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MetabolomicsFunctional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...

2021-04-01 | MTBLS923 | MetaboLights
MetabolomicsMetabolomics analysis of the toxic effects of the production of lycopene and its precursors
Using cells as microbial factories enables highly specific production of chemicals with many advantages over chemical syntheses. A number of exciting new applications of this approach are in the area of precision metabolic engineering, which focuses on improving the specificity of target production....
2021-02-11 | MTBLS642 | MetaboLights
MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
TranscriptomicsPurification of neuronal precursors from the adult mouse brain: a comprehensive gene expression analysis
The progeny of neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain consists in polysialylated NCAM-expressing immature neurons (PSA(+) cells), which migrate to the olfactory bulb (OB) to differentiate into GABAergic interneurons. We purified murine PSA(+) cells directly f...
ORGANISM(S): Mus musculus 
2007-09-21 | E-GEOD-9081 | biostudies-arrayexpress
GenomicsCharacterization of embryonic osteoclast precursors
Characterization of embryonic osteoclast precursors
PRJNA515201 | ENA
TranscriptomicsPhotoreceptor precursors derived from 3D cultures of embryonic stem cells mature and integrate in degenerate retina
To isolate photoreceptor precursors fit for transplantation, we adapted a 3D differentiation protocol that generates neuroretina from mouse ES cells. We used an adeno-associated viral vector (pseudotype2/9)carrying a GFP reporter under the control of a Rhodopsin promoter (AAV2/9.Rhop.GFP)to select r...
ORGANISM(S): Mus musculus 
2013-07-17 | E-MEXP-3921 | biostudies-arrayexpress
TranscriptomicsIdentification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors
This SuperSeries is composed of the following subset Series: GSE9603: Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray GSE9619: Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on ...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9620 | biostudies-arrayexpress
TranscriptomicsImmunomagnetic purification of mES derived neuronal precursors increases neuronal migration and differentiation in vivo
All established protocols for differentiation of mouse and human pluripotent stem cells into specific neural subpopulations generate a considerable cellular heterogeneity that hampers experimental and clinical progress. In order to obtain a homogenous population of neuronal precursor cells and to st...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-35125 | biostudies-arrayexpress
TranscriptomicsDirect genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (human)
Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mese...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57518 | biostudies-arrayexpress
GenomicsRNA-seq analysis of human expandable arterial endothelial precursors (eAEPs), expandable mesenchymal precursors (eMPs), and controls
RNA-seq analysis of human expandable arterial endothelial precursors (eAEPs), expandable mesenchymal precursors (eMPs), and controls
PRJNA418736 | ENA
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