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MetabolomicsPharmacokinetic and urinary profiling reveals prednisolone/cortisol ratio as a valid biomarker for prednisolone administration
In Europe, synthetic corticosteroids are not allowed in animal breeding fro growth-promoting purposes. Nevertheless, a high prevalence of non-compliant urine samples was recently reported for prednisolone, however, without any indication of unauthorized use. Within this context, 20b-dihydroprednisol...
2018-01-23 | MTBLS488 | MetaboLights
MetabolomicsMetabolic fingerprinting reveals a novel candidate biomarker for prednisolone treatment in cattle
The use of glucocorticoids as growth promoters for meat-producing animals is strictly regulated within the European Union. However, in the past few years, a higher frequency of non-compliant bovine urine samples for prednisolone has been noticed, which could not be directly related to fraudulent use...
2017-01-12 | MTBLS185 | MetaboLights
TranscriptomicsCCRF-CEM Prednisolone treatment at 4h
Background: Glucocorticoids are important pharmaceutical agents in the treatment of acute lymphoblastic leukemia in children. Resistance or sensitivity to glucocorticoids is considered to be of crucial importance for disease prognosis. Prednisolone is a first-line chemotherapeutic agent in the treat...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-27989 | biostudies-arrayexpress
TranscriptomicsPrednisolone-induced differential gene expression in liver of mice carrying the wild type or a dimerization-defective glucocorticoid receptor
Glucocorticoids control expression of a large number of genes after binding to the glucocorticoid receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although th...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21048 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile of thymus samples from prednisolone-treated and control cows.
A bovine oligo microarray platform (GPL7053) was used to evidence differences in gene expression profiles from eight (8) thymus samples from prednisolone-treated cows and seven (7) from control animals. Significance analysis of microarray found 154 up-regulated and 234 down-regulated transcripts in ...
ORGANISM(S): Bos taurus 
2014-09-02 | E-GEOD-40884 | biostudies-arrayexpress
TranscriptomicsGene expression data from children diagnosed with ALL in vitro sensitive or resistant to prednisolone
Although the prognosis for childhood Acute Lymphoblastic Leukemia (ALL) in general has improved tremendously over the last decades, the survival chances for infants (<1 year of age) with ALL remains poor. A major obstacle hampering successful treatment results in infant ALL is cellular resistance to...
ORGANISM(S): Homo sapiens 
2009-12-15 | E-GEOD-19143 | biostudies-arrayexpress
ProteomicsPrednisolone alters decidualization and affects decidual-trophoblast interactions
Identification of cellular proteins in human endometrial stromal fibroblasts decidualized for 13 days in vitro. Fibroblasts were cultured under normal culture conditions (5% CO2 in 2% charcoal stripped FBS) and treated with prednisolone (0.5ug/ml) or vehicle control (DMSO) every 48-72h for 13 days
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD020543 | Pride
Prednisolone  decidualization  trophoblast  recurrent pregnancy loss  repeated implantation failure Human Label free quantification Lcms 
TranscriptomicsCCRF-CEM Prednisolone and MG132 treatments at 4h
Background: The combination of Proteasome inhibitor with Glucocorticoid is one of the most promising antileukemic treatments. Both agents act through pluripotent signal mediators. The two types of agents inhibit key signals that are considered crucial to their effects on malignant cells. Methodology...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-29136 | biostudies-arrayexpress
TranscriptomicsImmune correlates of early prednisolone therapy in children and adolescents with dengue
Dengue is the most important arboviral infection of humans. A host pro-inflammatory immune response is widely believed to contribute to the clinical complications that occur in some patients with dengue. Here, immune correlates of early prednisolone therapy were defined in Vietnamese dengue patient...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-40165 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muscle and liver tissue in collagen-induced arthritis (CIA) and control mice treated with increasing doses of prednisolone
Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Although GCs are predominantly prescribed for treatment of inflammatory conditions, little is known about their long-term effects on gene-expression in-vivo during inflammation. Here...
ORGANISM(S): Mus musculus 
2013-11-10 | E-MTAB-1765 | biostudies-arrayexpress
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