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GenomicsIL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-64844 | biostudies-arrayexpress
TranscriptomicsAlternatively activated mononuclear phagocytes from the skin site of infection and the impact of IL-4Rα signaling on CD4+T cell survival in draining lymph nodes after repeated exposure to Schistosoma mansoni cercariae
In areas endemic for schistosomiasis, repeated exposure to infective cercariae is a frequent occurrence, and repeated exposure of murine skin to Schistosoma mansoni resulted in CD4+ T cells becoming hypo-responsive. Here potential contributory mechanisms were investigated. In the skin infection site...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-81938 | biostudies-arrayexpress
UnknownHIV-associated anemia after 96 weeks on therapy: determinants across age ranges in Uganda and Zimbabwe.
Not available
S-EPMC4046193 | biostudies-literature
Genomicsena-DATASET-IGMM-28-09-2016-11:49:17:763-561 - samples
Exome sequencing of isolate populations and Generation Scotland
EGAD00001002715 | EGA
GenomicsHomozygous loss-of-function variants in European cosmopolitan and isolate populations
Homozygous loss of function (HLOF) variants provide a valuable window on gene function in humans, as well as an inventory of the human genes that are not essential for survival and reproduction. All humans carry at least a few HLOF variants, but the exact number of inactivated genes that can be tole...
EGAS00001001606 | EGA
GenomicsQTL-DAC
Data Access Committee EGAC00001000063
EGAC00001000063 | EGA
UnknownAssociations Between Eight Earth Observation-Derived Climate Variables and Enteropathogen Infection: An Independent Participant Data Meta-Analysis of Surveillance Studies With Broad Spectrum Nucleic Acid Diagnostics.
Not available
S-EPMC8729196 | biostudies-literature
UnknownSpatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data.
Not available
S-EPMC10020138 | biostudies-literature
UnknownMicrobial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.
Not available
S-EPMC6284549 | biostudies-literature
UnknownOpportunities and challenges for monitoring terrestrial biodiversity in the robotics age.
Not available
S-EPMC12148927 | biostudies-literature
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