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TranscriptomicsMicroarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
The purpose of this experiment was to determine the transcriptional differences between neural progenitor cells from neonatal lung injury mice vs. control mice, as well as neonatal lung injury mice treated with umbilical-cord mesenchymal stromal cell extracellular vesicles vs. neonatal lung injury m...
ORGANISM(S): Mus musculus 
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
ProteomicsProteomics analysis of preterm lung tissue with mass spectrometry to understand the impact of bias gas flow strategy at birth
This study aimed to use a lamb model of preterm birth to investigate the impact of different bias gas flow strategies, applied during positive pressure ventilation, on lung injury development. Preterm lambs were ventilated for a total of 90 minutes. A group of lambs was euthanised at birth to act as...
ORGANISM(S): Ovis aries 
2025-05-06 | PXD050305 | Pride
Lung proteomics Preterm lung injury Bias gas flow 
ProteomicsRegulation of hyperoxia-induced neonatal lung injury via posttranslational cysteine redox modifications
Lung tissue from normoxia- or hyperoxia-treated control or SCNN1B overexpression mice were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-18 | MSV000090157 | MassIVE
ProteomicsProteomics analysis of preterm lung tissue with mass spectrometry to understand the impact of tidal volume strategy at birth
This study aimed to use a lamb model of preterm birth to investigate the impact of different tidal volume strategies, applied during positive pressure ventilation, on lung injury development. Preterm lambs were ventilated for a total of 15 minutes, followed by a 30 minute ‘rest’ period where lambs w...
ORGANISM(S): Ovis aries 
2023-10-09 | PXD041917 | Pride
Ventilation Proteomics Tmt Lung Tissue damage Sheep 
ProteomicsEnvironmental Pollutant Induced Cellular Injury is Reflected in Exosomes from Placental Explants
Environmental exposure of placental explants did not change the quantity of exosomes or their characteristics. However, exosome cargo composition was changed by specific pollutant to reflect a biochemical signature suggestive of placental nuclear and cellular injury and inflammation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084274 | MassIVE
Transcriptomicspreparative changes in rat intestine and lung for birth
To identify genes important in fetal preparation for birth. Transcript profiling using microarray analysis was performed using lung and intestine RNA from a single animal from each of 10 litters at a given gestational age. Array experiments were performed by the Genomics CoreLab, Cambridge Comprehen...
ORGANISM(S): Rattus norvegicus 
2010-11-21 | E-GEOD-16849 | biostudies-arrayexpress
GenomicsHuman Muse cells isolated from preterm- and term-umbilical cord delivered therapeutic effects in rat bleomycin-induced lung injury model without immunosuppressant
Human Muse cells isolated from preterm- and term-umbilical cord delivered therapeutic effects in rat bleomycin-induced lung injury model without immunosuppressant
PRJNA1100522 | ENA
TranscriptomicsChoriodecidual Infection Downregulates Angiogenesis and Morphogenesis Pathways in Fetal Lungs from Macaca Nemestrina
Intrauterine exposure to amniotic fluid (AF) cytokines is thought to predispose to bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD. Ten ...
ORGANISM(S): Macaca nemestrina 
2013-04-23 | E-GEOD-39029 | biostudies-arrayexpress
TranscriptomicsHuman Muse cells isolated from preterm- and term-umbilical cord delivered therapeutic effects in rat bleomycin-induced lung injury model without immunosuppressant
Background Bleomycin (BLM)-induced lung injury is characterized by the mixed histopathologic changes with inflammation and fibrosis. These changes are also observed in human patients with bronchopulmonary dysplasia, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. Although n...
ORGANISM(S): Homo sapiens 
2024-04-18 | GSE263992 | GEO
UnknownRespiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung.
Not available
S-EPMC9753394 | biostudies-literature
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