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MetabolomicsFecal metabolomic study in patients with choledocholithiasis concurrent with cholangitis

Metabolites associated with the gut microbiota play an important role in the pathogenesis of choledocholithiasis concurrent with cholangitis (CC). This study aims to characterize the fecal metabolite profile of CC patients and to investigate the correlation and balance within the gut cross-domain...

2025-08-11 | MTBLS12772 | MetaboLights
TranscriptomicsRNA-seq of human hepatic arteries in a study of primary sclerosing cholangitis
PSC is a chronic inflammatory condition of the biliary tree causing biliary strictures and fibrosis and predisposes to cholangiocarcinoma. Traditionally it is considered a primary disorder of the bile duct epithelia. Here we investigate whether injury to the arterial blood supply may contribute to P...
ORGANISM(S): Homo sapiens 
2023-07-01 | E-MTAB-11917 | biostudies-arrayexpress
ProteomicsBottom-up Proteomics of Saliva in Autoimmune Hepatitis and Primary Biliary Cholangitis
Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC) are autoimmune diseases that target the liver in which the immune system produces an inappropriate response to self-antigens resulting in inflammation, damage, and dysfunction of hepatic tissues. Despite progress in the understanding o...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039847 | Pride
Autoimmune hepatitis Saliva Primary biliary cholangitis Bottom-up proteomics Autoimmune liver diseases Lc-ms/ms 
GenomicsItalian Primary Biliary Cirrhosis Study

A Genome-wide association study of primary biliary cirrhosis (PBC) with an Italian cohort and loci meeting suggestive criteria were confirmed using a replication dataset from a previous Canadian study. The results confirmed associations for IL12A, IL12RB2, and HLA (peak between DQA1 and DQB1) and...

phs000444.v1.p1 | EGA
GenomicsWTCCC3 case-control study for Primary Biliary Cirrhosis
Genome-wide association scan was performed in 1,840 cases of primary biliary cirrhosis and 5,163 controls. Replication of new associations was tested in an independent set of 620 cases and 2,514 controls.
EGAS00000000039 | EGA
ProteomicsProteomic Profiling of Liver and Plasma Uncovers Biomarkers and Mechanisms in Patients with Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a rare autoimmune liver disease that can progress to fibrosis and cirrhosis. We applied untargeted mass spectrometry-based proteomic analysis to paired liver and plasma samples from patients with newly diagnosed PBC, patients with metabolic dysfunction-associated...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD083842 | Pride
Primary biliary cholangitis  proteomics  plasma proteomics  liver proteomics  mass spectrometry 
TranscriptomicsEffect of pharmacological inhibition of ASBT on bile composition and sclerosing cholangitis in mdr2 knockout mice
We report the effect of a potent pharmacological inhibition of ASBT in mdr2 -/- mice, compared to genetic and treatment controls using RNA-sequencing. Through quantification of mRNA in liver samples, we found significant upregulation of anti-inflammatory and anti-fibrotic gene signatures in mdr2-/-...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-66231 | biostudies-arrayexpress
GenomicsCCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis
CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis
PRJNA950414 | ENA
ProteomicsSerum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia.
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and an increased risk of cholangiocarcinoma (CCA). Here, we have used label-free quantitative proteomics to analyze serum and bile samples from non-PSC controls and PSC patients, as well...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026693 | Pride
Human Bile Mass spectrometry Neoplasia Psc 
ProteomicsSerum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia (BILE)
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and an increased risk of cholangiocarcinoma (CCA). Here, we have used label-free quantitative proteomics to analyze serum and bile samples from non-PSC controls and PSC patients, as well...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026694 | Pride
Human Bile. psc. mass spectrometry 
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