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TranscriptomicsTranscription profiling of human normal and cadaver primary open-angle glaucoma donors
The total RNA from control and POAG optic nerve lamina cribrosa region was isolated and subjected to analysis on U133A 2.0 affymetrix microarray chip. The results from these two analysis was compared to determine whether PAD II RNA level is altered. Purpose of the study. This study was done to dete...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2387 | biostudies-arrayexpress
ProteomicsDysregulated proteins in aqueous humor from primary open angle glaucoma patients with clinical correlation
Primary open angle glaucoma (POAG) presents as an irreversible optic neuropathy with corresponding visual field deficits and no other notable symptoms. The pathophysiology of POAG remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify chan...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD033153 | Pride
Proteomics Tmt Primary open angle glaucoma Aqueous humor Lc-ms/ms 
TranscriptomicsSmall RNA-seq Aqueous humor of human glaucoma (open-angle glaucoma and pseudoexfoliative glaucoma) patients against cataract
Study investigates the biological role of small RNAs present in aqueous humor in patients with primary open-angle glaucoma, pseudoexfoliative glaucoma, and cataract, with the aim of identifying molecular biomarkers and improving understanding of disease mechanisms. Aqueous humor samples were collect...
ORGANISM(S): Homo sapiens 
2026-04-30 | E-MTAB-16859 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human trabecular meshwork cultured cells, non-glaucomatous and POAG tissue
The goal of this study was to contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells, to that of control and primary open angle glaucoma (POAG) HTM tissues. Total RNA from cultured HTM cells and HTM tissue dissected from control and POAG anterior segments fix...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4316 | biostudies-arrayexpress
GenomicsThe Primary Open-Angle Glaucoma Genes and Environment (GLAUGEN) Study

Background Information: Primary open-angle glaucoma (POAG) is an age-related, intraocular pressure (IOP)-dependent progressive optic neuropathy that ultimately leads to irreversible blindness. Vision loss from POAG is a condition of public health significance. Current evidence suggests tha...

phs000308.v1.p1 | EGA
ProteomicsA quantitative spectral library of human aqueous humor was analyzed using TimsTOFTM Pro Bruker for primary open angle glaucoma (POAG).
Globally, irreversible vision loss is mainly attributed to glaucoma, a complex eye condition. Given that the progression of glaucoma is challenging to detect and track, and reliable predictive markers are lacking, there is an urgent need for biomarkers. In this context, the aqueous humor, which is p...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD060484 | Pride
Poag Human aqueous humor Primary open-angle glaucoma 
ProteomicsHuman aqueous humor of Primary open angle glaucoma LC-MS/MS
The main objective of this study was to adopt discovery based approach and define quantitative expression of human AH samples of glaucoma (N= 5) and non-glaucoma subjects (N=5) by using a state-of-the-art high performance liquid chromatography coupled mass spectrometry, to establish the relative reg...
ORGANISM(S): Homo sapiens (Human) 
2018-06-15 | PXD007624 | Pride
Primary open angle glaucoma 
GenomicsThe Primary Open-Angle Glaucoma Genetics Study (POAAGG)
The Primary Open-Angle Glaucoma Genetics Study (POAAGG)
PRJNA377379 | ENA
GenomicsConstruction of miRNA-mRNA Regulatory Network Indicates Potential Biomarkers for Primary Open-Angle Glaucoma
Construction of miRNA-mRNA Regulatory Network Indicates Potential Biomarkers for Primary Open-Angle Glaucoma
PRJNA967639 | ENA
ProteomicsProfiling of the proteome of peripheral blood mononuclear cells of subjects diagnosed with primary open angle glaucoma
This study reports the first characterization of the intracellular proteome of peripheral blood mononuclear cells (PBMC) isolated from subjects diagnosed with primary open angle glaucoma (POAG)by shot-gun proteomics. Glaucoma is a chronic optic neuropathy and among the first causes of irreversible...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD059976 | Pride
Glaucoma Peripheral blood mononuclear cells Shot gun proteomics Immune system 
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