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TranscriptomicsComparison of Glomerular and Podocyte mRNA Profiles in eNOS-/- Diabetic Mice Induced by Streptozotocin
We compared mRNA profiles of isolated glomeruli versus sorted podocytes between diabetic and control mice. IRG mice crossed with eNOS-/- mice were further bred with podocin-rTTA and TetON-Cre mice to permanently label podocytes before the diabetic injury. Diabetes was induced by injection of strepto...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79291 | biostudies-arrayexpress
GenomicsGlucocorticoid receptor ChIP-seq in an immortalized podocyte cell line
The identification of the glucocorticoid receptor cistrome in a conditionally immortalized human podocyte cell line developed by transfection with the temperature-sensitive SV40-T gene
ORGANISM(S): Homo sapiens 
2017-07-17 | E-MTAB-5238 | biostudies-arrayexpress
TranscriptomicsRNA expression data from glomeruli lacking von Hippel-Lindau protein in podocytes
We and others have previously shown that glomerular endothelial cells and podocytes express hypoxia-inducible transcription factors (HIFs). HIFs bind to hypoxia response elements in target genes, such as vascular endothelial growth factor, which is continually produced by podocytes throughout life....
ORGANISM(S): Mus musculus 
2010-08-03 | E-GEOD-20235 | biostudies-arrayexpress
ProteomicsTestican-2 interaction with the extracellular matrix and podocyte protection
Background: Testican-2 is a podocyte-derived glycoprotein encoded by SPOCK2. Circulating levels of testican-2 are associated with less glomerulosclerosis and better kidney prognosis, but its biological function in the podocyte is unknown. Methods: We studied the protective effect of testican-2 on ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD066935 | Pride
Testican-2 binding protein Podocyte Human 
ProteomicsDeep mapping of the mouse podocyte proteome
We analyzed the proteome of mouse FACS-sorted podocytes. We compared podocytes ("green cells") with non-podocyte ("red cells") cells of the glomerulus.
ORGANISM(S): Mus musculus (Mouse) 
2018-06-21 | PXD003306 | Pride
Mouse Podocyte Kidney 
ProteomicsHuman podocyte cell culture degradomics
Regulated intracellular proteolysis is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. Altered proteolytic substrate turnover has been associated with various glomerular diseases ranging from diabetic nephropathy to focal and segmental glomeru...
ORGANISM(S): Homo sapiens (Human) 
2017-07-20 | PXD005140 | Pride
Human podocyte cell culture Tails Pan challenge 
TranscriptomicsMicroarray Study Reveals Hormone-Modulated Gene Transcription During Human Podocyte Differentiation
Glomerular podocytes are highly differentiated kidney cells that constitute one of the key components responsible for removing toxins and metabolic waste while preserving nutrients in the bloodstream in the renal glomerulus. In addition, podocytes contribute significantly to the formation of the glo...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-39823 | biostudies-arrayexpress
ProteomicsDisruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Kinase inhibitors (KIs) used in cancer therapeutics are associated with various side effects. One of the most significant adverse events that lead to discontinuation or modification of treatment is nephrotoxicity. We have identified BCR-ABL1 inhibitor dasatinib as a potential glomerular nephrotoxin ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-29 | PXD011761 | Pride
Podocyte  kidney  dasatinib  bcr-abl  nephrotoxicity  cytoskeleton  actin  biophysics 
TranscriptomicsRNA-seq of primary mouse podocytes with KDM6A overexpression against controls
We performed RNA-seq experiments (three replicates) on primary mouse podocytes that were infected with control lentivirus or KDM6A-encoding lentiviruses. RNAs were first extracted using Trizol reagent (Invitrogen, USA) according to the manufacturer’s instruction. The purified RNAs were quantified at...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7695 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of WT1-controlled gene expression in podocytes
We identified binding sites of the Wilms' tumor suppressor protein WT1 in the mouse podocyte genome in vivo by ChIP-seq. Furthermore, we provide a podocyte transcriptome derived from primary podocytes that were isolated by FACS on mouse glomeruli. In short, we show that WT1 activates a highly specif...
ORGANISM(S): Mus musculus 
2014-12-11 | E-GEOD-64063 | biostudies-arrayexpress
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