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MetabolomicsThe functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells

Human embryonic stem cells (hESCs) can self-renew infinitely or differentiate into the 3 germ layer lineages in vitro with certain cues, holding great promise to model early human embryo development ex vivo. It is wildly accepted that hESCs take advantage of both glycolysis and ...

2022-03-03 | MTBLS4223 | MetaboLights
MetabolomicsCommon mycelial network modulates neighbour-primed plant defences against foliar pathogens by co-opting distinct inter-plant metabolic and biotic stress responses
This study contains raw and processed mass spectrometry-based metabolomics data from Medicago truncatula plants used to investigate inter-plant signalling through arbuscular mycorrhizal fungal common mycelial networks. The experiment examined metabolomic responses in receiver plants following stress...
2026-06-30 | MTBLS14821 | MetaboLights
TranscriptomicsTranscription profiling of IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-1925 | biostudies-arrayexpress
ProteomicsTranslational and Post-translational LC-MS of Naïve and Primed hESCs
Deciphering the regulatory network for human naïve and primed pluripotency is of fundamental theoretical and applicable significance. Here, by combining quantitative proteomics, phosphoproteomics and acetylproteomics analyses, we revealed RNA processing and translation as the most differentially-reg...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD030230 | Pride
Lc-ms Primed Human Hesc Naïve 
TranscriptomicsReorganization of enhancer patterns in transition from naïve to primed pluripotency (RNA-seq)
Naïve and primed pluripotency is characterized by distinct signaling requirements, transcriptomes and developmental properties, but both cellular states share key transcriptional regulators, Oct4, Sox2 and Nanog. Here we demonstrate that transition between these two pluripotent states is associated ...
ORGANISM(S): Mus musculus 
2014-06-05 | E-GEOD-56096 | biostudies-arrayexpress
TranscriptomicsChromatin accessibility in naive and primed HeLa cells upon IFNγ treatment
chromatin accessibility (ATAC-seq) experiment. HeLa cells were primed with IFNγ for 24 hours, followed by IFNγ washout. After 48h, naïve and primed cells were induced by IFNγ for 1h and 3h. Cells were harvested at indicated time points and processed for ATAC-seq.
ORGANISM(S): Homo sapiens 
2023-05-06 | E-MTAB-12624 | biostudies-arrayexpress
TranscriptomicsSTAT1 and IRF1 enrichment in naive and primed HeLa cells upon IFNγ treatment
STAT1 and IRF1 transcription factor enrichment by CUT&RUN. HeLa cells were primed with IFNγ for 24 hours, followed with IFNγ washout. After 48h, naïve and primed cells were induced by IFNγ for 1h and 3h. Cells were harvested at indicated time points and processed for CUT&RUN
ORGANISM(S): Homo sapiens 
2023-05-06 | E-MTAB-12625 | biostudies-arrayexpress
GenomicsReorganization of enhancer patterns in transition from naïve to primed pluripotency (ChIP-seq)
Naïve and primed pluripotency is characterized by distinct signaling requirements, transcriptomes and developmental properties, but both cellular states share key transcriptional regulators, Oct4, Sox2 and Nanog. Here we demonstrate that transition between these two pluripotent states is associated ...
ORGANISM(S): Mus musculus 
2014-06-05 | E-GEOD-56098 | biostudies-arrayexpress
ProteomicsCell-surface proteomics identifies differences in signalling and adhesion protein expression between naive and primed human pluripotent stem cells
Naive and primed human pluripotent stem cells (hPSC) provide valuable models to study cellular and molecular developmental processes. The lack of detailed information about cell-surface protein expression in these two pluripotent cell types prevents an understanding of how the cells communicate and ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-17 | PXD015359 | Pride
Naive and primed human pluripotent stem cells Plasma membrane profilling 
GenomicsNaïve and Primed MSC derived exosomes
Naïve and Primed MSC derived exosomes
PRJNA575856 | ENA
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