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TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
TranscriptomicsCytokine stimulation systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Background: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic potential of coronaviruses and the severe disease these etiologic agents can cause in humans. Clinical features of Middle East respiratory syndrome (MERS) include severe acu...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56677 | biostudies-arrayexpress
TranscriptomicsFever-range temperature alters continual efferocytosis mediated by mouse pro-inflammatory macrophages
Fever, a cardinal sign of inflammation, has been shown to modulate macrophage functions. Here, we wonder whether fever affects macrophage efferocytosis. This process is critical for the resolution of inflammation and the return to homeostasis with the reprogramming of macrophages toward a pro-resolv...
ORGANISM(S): Mus musculus 
2025-12-19 | E-MTAB-14408 | biostudies-arrayexpress
ProteomicsProteomic phenotyping of stimulated Müller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity
Müller cells are the main macroglial cells of the retina exerting a wealth of functions to maintain retinal homoeostasis. Upon pathological changes in the retina, they become gliotic with both protective and detrimental consequences. Accumulating data also provide evidence for a pivotal role of Müll...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-02-16 | PXD028390 | Pride
Pro-inflammatory Complement system Cytokines. retina Immune response Müller cells Atypical antigen-presenting cell Diabetic retinopathy 
GenomicsSASP signature of beta-cells includes pro-inflammatory and stress response proteins
SASP signature of beta-cells includes pro-inflammatory and stress response proteins
PRJNA631719 | ENA
ProteomicsEntamoeba histolytica extracellular vesicles drive pro-inflammatory monocyte signaling
The parasitic protozoan Entamoeba histolytica secretes extracellular vesicles (EVs), but so far little is known about their function in the interaction with the host immune system. Infection with E. histolytica trophozoites can lead to formation of amebic liver abscesses (ALAs), in which pro-inflamm...
ORGANISM(S): Entamoeba histolytica 
2025-03-06 | PXD059636 | Pride
Extracellular vesicles Entamoeba histolytica 
GenomicsEngineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity
Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity
PRJNA1141569 | ENA
ProteomicsPersistent inflammatory stimulation drives the transition of MSCs to inflammatory CAFs that promote pro-metastatic characteristics in breast cancer cells
The pro-inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β) are expressed simultaneously and have tumor-promoting roles in breast cancer. In parallel, mesenchymal stem cells (MSCs) undergo transition at the tumor site to cancer-associated fibroblasts (CAFs), which are ge...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD022635 | Pride
Breast cancer  cancer-associated fibroblasts  inflammation  interleukin 1β  mesenchymal stem cells  tumor necrosis factor α. 
ProteomicsPro-inflammatory activity following demyelinating injury is required for phagocytic function and oligodendrocyte formation
Remyelination can occur naturally in demyelinating lesions, but often fails in human demyelinating diseases such as multiple sclerosis (MS). The function of the innate immune system is essential for the regenerative response, but how exactly microglia and macrophages clear myelin debris after injury...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD014625 | Pride
Myd88 Myelin Mouse Microglia 
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