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MetabolomicsBiomarker Discovery in Oral Cancer (OSMF & OSCC) and its severity

Oral squamous cell carcinoma (OSCC) is frequently the outcome of oral submucous fibrosis (OSMF), a common possibly premalignant disease. In our study, a cohort of 50 patients with OSCC and OSMF, along with 50 healthy controls, was analyzed to identify significant metabolic differences between the...

2024-10-23 | MTBLS11009 | MetaboLights
MetabolomicsMetabolomics-Driven Discovery of an Introduced Species and Two Malaysian Piper betle L. Variants
The differences in pungency of 'sirih' imply the probable occurrence of several variants of Piper betle L. in Malaysia. However, the metabolite profiles underlying the pungency of the different variants remain a subject of further research. The differences in metabolite profiles of selected M...
2022-03-21 | MTBLS2585 | MetaboLights
MetabolomicsMaHPIC Experiment HuB - Metabolomics analysis of human plasma from patients infected with Plasmodium falciparum and P.vivax for discovery of diagnostic markers of malaria
MaHPIC Experimental Description:
This study is based on archived plasma from samples collected between 2011 and 2014. Patients in Thailand who were infected with Plasmodium falciparum (30 subjects), P. vivax (30 subjects), co-infected with P. falciparum and P. viv...
2018-09-05 | MTBLS664 | MetaboLights
TranscriptomicsSingle feature polymorphism array 16K Unigenes: marker discovery in melon
One of the methods used to search for molecular markers is DNA hybridization to microarrays. Microarray hybridization of DNA from different individuals can reveal differences between them (single-feature polymorphisms (SFPs)). These SFPs can be used as markers for breeding purposes, or they can be c...
ORGANISM(S): Cucumis melo subsp. melo 
2010-08-01 | E-GEOD-17673 | biostudies-arrayexpress
ProteomicsElectrophile scanning by chemical prote-omics reveals a potent pan-active DUB probe for investigation of deubiquitinase activity in live cells
Deubiquitinases (DUBs) are proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates, which can lead to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of DUB activity has been im-plicated in many disease states, including cancer, neurodege...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD035417 | Pride
Ubiquitin-activity base probe Deubiquitinase Chemical probe Activity-based probe Electrophilic war-head Ubiquitin Dub Enzyme targeting Myc-deregulated cancer 
ProteomicsDiscovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6
Cellular selectivity of a chemical probe for the UBD of HDAC6. A biotinylated analog of HDAC6 chemical probe SGC-UBD253 bound to streptavidin beads was used to enrich HDAC6 from cytoplasmic fraction of HEK293 lysate. A triplicate of each condition - competition with probe, control, DMSO - was done.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039880 | Pride
Ubiquitin binding domain Chemical probe Ubd Chemoproteomics Hdac6 
UnknownDiscovery of an MLLT1/3 YEATS Domain Chemical Probe.
Not available
S-EPMC6348381 | biostudies-literature
GenomicsFunction-first proteomic strategies for chemical probe discovery in human cells
Function-first proteomic strategies for chemical probe discovery in human cells
PRJNA768835 | ENA
MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
TranscriptomicsDiscovery of novel imprinted genes by transcriptional analysis of parthenogenetic embryonic stem cells
Parthenogenetic embryonic stem cells (PESCs) may have future utility in cell replacement therapies. We examined genome-wide mRNA expression profiles of monkey PESCs relative to ESCs derived from fertilized embryos. Several known paternally-imprinted genes were in the highly down-regulated group in P...
ORGANISM(S): Macaca mulatta 
2010-07-07 | E-GEOD-17964 | biostudies-arrayexpress
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