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ProteomicsExperimental maceration of bovine bones and its effects on the bone proteome
This study is aimed at understanding how bone soft maceration procedures (e.g., soaking the bones in warm water with the aid of detergents) used to process bones for long term storage (e.g., in human osteological collections) affect the bone proteome. Three different maceration protocols have been t...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-08 | PXD032295 | Pride
Maceration Bone Shotgun proteomics 
ProteomicsBone Diagenesis in Short Timescales: Insights from an Explor-atory Proteomic Analysis
The evaluation of bone diagenetic phenomena in archaeological timescales has a long history, however little is known about the origins of the microbes driving bone diagenesis and on the ex-tent of bone diagenesis on short timeframes such as in forensic contexts. Previously, the analysis of non-colla...
ORGANISM(S): Rattus rattus (Black rat) 
2022-02-17 | PXD026042 | Pride
Taphonomy  bone proteomics  pmi  microbial decomposition  bioerosion 
ProteomicsAquatic decomposition and its effects on the bone proteome for forensic applications
Methods currently available to estimate the post-mortem submerged interval (PMSI) of cadavers in water suffer from poor accuracy, being mostly based on morphological examination of the remains. Proteins present within bones have recently attracted more attention from researchers interested in the es...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-06 | PXD017386 | Pride
Bone Forensic Aquatic decomposition 
ProteomicsInsights on the Differential Preservation of Bone Proteomes in Inhumated and Entombed Cadavers from Italian Forensic Caseworks
Bone is a long-lasting biological tissue often used in forensic investigations as it retains vital biomolecular information commonly used for identification purposes. Bone proteins have attracted interest for their potential in estimating post-mortem interval (PMI) and age-at-death (AAD). However, t...
ORGANISM(S): Homo sapiens (Human) 
2022-03-25 | PXD029911 | Pride
Forensics Age-at-death Bone Burial environment Post-translational protein modifications Post-mortem interval 
ProteomicsThe implications of taphonomic alteration of human bone protein profiles for the development of a bone proteomics PMI/AAD estimation method.
The estimation of the post-mortem interval (PMI) and the age-at-death (AAD) are crucial steps in the medico-legal investigation of unidentified human remains. Current methods to estimate PMI and AAD suffer from a lack of accuracy and objectivity, particularly when the remains are in an advanced stat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019693 | Pride
Forensic proteomics Post-mortem interval Taphonomy Chronological ageing Bone proteomics 
ProteomicsBone proteomics methods optimisation for forensic investigations
The application of human bone in forensic proteomics is an expanding novel purpose in the aim of successfully quantifying biological estimations used in medico-legal investigations with greater accuracy. In this project, different extraction protocols were tested on n=30 human bone samples, includi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-10 | MSV000093803 | MassIVE
ProteomicsProteome variation with collagen yield in ancient bone
Isotope analyses are some of the most common analytical methods applied to ancient bone, aiding the interpretation of past diets and chronology. For this, the evaluation of “collagen” yield is a routine step that allows for the selection of the specimens that are adequate for subsequent analyses, an...
ORGANISM(S): Bos taurus (Bovine) Cervus elaphus (Red deer) Homo sapiens (Human) Equus caballus (Horse) 
2021-02-08 | PXD020516 | Pride
Proteomics  ancient bone  collagen  ncps  radiocarbon dating  stable isotopes. 
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