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ProteomicsProtein-protein interactions of the N-terminal region of PRPF40A
A SILAC-based quantitative affinity purification experiment was performed to study the protein binders of the N-terminal region (1-310) of PRPF40A and its mutated version with the proline-rich sequence substituted by a polyalanine stretch.
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD046164 | Pride
Ap-ms Human Proline-rich region Prpf40a 
ProteomicsStructural Insights into the Role of the Proline Rich Region in Tau Function
Tau is a microtubule-associated protein that plays an important role in modulating axonal microtubules in neurons. Intracellular tau aggregates are found in a broad class of disorders, including Alzheimer’s disease, termed tauopathies. Tau is an intrinsically disordered protein, and its structural d...
ORGANISM(S): Escherichia coli 
2025-01-31 | PXD059518 | Pride
Post-translational modifications Alzheimer's disease Tubulin Tau Phosphorylation Microtubules Aggregation 
TranscriptomicsThe Estrogen Receptor Co-Regulator Protein, Proline Glutamic Acid and Leucine Rich Protein 1 (PELP1) Mediates Estrogen Rapid Signaling and Neuroprotection in the Brain
We examined the role of PELP1 in E2-ER-mediated transcription in the hippocampus under conditions of GCI by perfroming global transcriptome analysis. E2-treated FLOX and PELP1 FBKO mice were subjected to GCI followed by 24 h reperfusion and the isolated RNA was utilized for RNA-seq analysis. Our res...
ORGANISM(S): Mus musculus 
2015-12-07 | E-GEOD-72136 | biostudies-arrayexpress
ProteomicsPRR of Tau Crosslinking with Tubulin
We used cross-linking mass spectrometry with the cleavable cross-linker, disuccinimidyl dibutyric urea (DSBU) to map sites of interaction between the proline rich domain (PRR, tau amino acids 149-244) and tubulin. For comparison, we also conducted these experiments with PRR constructs containing mul...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli 
2026-03-09 | PXD049384 | Pride
Tubulin Tau Phosphorylation Proline rich region 
GenomicsA Missense Variant in CASKIN1's Proline-Rich Region Segregates with Psychosis in a Three-Generation Family
A Missense Variant in CASKIN1's Proline-Rich Region Segregates with Psychosis in a Three-Generation Family
PRJNA1116993 | ENA
UnknownProline-Rich Hypervariable Region of Hepatitis E Virus: Arranging the Disorder.
Not available
S-EPMC7564002 | biostudies-literature
UnknownQuantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer's disease.
Not available
S-EPMC12647631 | biostudies-literature
TranscriptomicsA Missense Variant in CASKIN1's Proline-Rich Region Segregates with Psychosis in a Three-Generation Family
The polygenic nature of schizophrenia (SCZ) implicates many variants in disease development. Rare variants of high penetrance have been shown to contribute to the disease prevalence. Whole-exome sequencing of a large three-generation family with SCZ and bipolar disorder identified a single segregati...
ORGANISM(S): Homo sapiens 
2024-05-30 | GSE268384 | GEO
UnknownA proline-rich region with a highly periodic sequence in Streptococcal beta protein adopts the polyproline II structure and is exposed on the bacterial surface.
Not available
S-EPMC151936 | biostudies-literature
GenomicsFoxp3 regulates gene expression mostly via its proline-rich interaction region independent of its own DNA-binding domain
Foxp3 regulates gene expression mostly via its proline-rich interaction region independent of its own DNA-binding domain
PRJEB7453 | ENA
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