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TranscriptomicsChIP-chip study aimed at the identification of the repertoire of FOXC2 binding sites affected by the loss of FOXC2 phosphorylation in primary human lymphatic endothelial cells (LECs)
Chromatin immunoprecipitation microarray (ChIP-chip) study using anti-Myc (9E10) antibodies and primary human lymphatic endothelial cells (LECs) transduced with recombinant adenoviruses expressing wild type or phosphorylation-deficient Myc-tagged FOXC2.
ORGANISM(S): Homo sapiens 
2013-07-13 | E-MTAB-596 | biostudies-arrayexpress
ProteomicsH3K79 methyltransferase Dot1p/DOT1L is phosphorylated by proline-directed MAP kinases Hog1p and p38/MAPK11
Disruptor of telomeric silencing (Dot1p) is an exquisitely conserved histone methyltransferase, and is the sole enzyme responsible for H3K79 methylation in the budding yeast, Saccharomyces cerevisiae. It has been shown to be highly phosphorylated in vivo; however, the upstream kinases that act on Do...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-01-29 | PXD036747 | Pride
Yeast Signalling Post-translational regulation Histone methylation Epigenetics Chromatin 
UnknownProline-Directed Androgen Receptor Phosphorylation.
Not available
S-EPMC4389684 | biostudies-literature
ProteomicsCyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation
Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear. Using a fixed cell kinase assay and phosphoproteomics, we studied how CDK1 activity and non-catalytic CDK1 subunits contribute to the choice of...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD034098 | Pride
Cell cycle Cdk1 Kinase Phosphoproteomics 
ProteomicsTargeting GSK3β's S/T-P Kinase Activity with an Interface-Specific Nanobody Reduces Ischemic Stroke Injury via Ferritin Nanoparticle Delivery
Proline-directed (S/T-P) phosphorylation constitutes a fundamental yet incompletely understood neural signaling mechanism implicated in cerebral pathophysiology, including ischemic stroke. Building on our prior identification of a regulatory domain controlling the proline-directed kinase activity of...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD067942 | Pride
Nanobody Gsk3β Neuroprotection Hfn nanoparticle Ischemia stroke Proline-directed phosphorylation 
ProteomicsSite-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation (part 2)
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0â??SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structuralâ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080869 | MassIVE
ProteomicsSite-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation (part 1)
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0â??SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structuralâ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080812 | MassIVE
ProteomicsH3K79 methyltransferase Dot1p/DOT1L is phosphorylated by proline-directed MAP kinases Hog1p and p38/MAPK11
In vitro phosphorylation assays were conducted to identify phosphorylation sites on Dot1p catalysed by Hog1p. As several other kinases were co-purified with Hog1p, dead kinase control assays (Hog1p-K52R and Hog1p-D144A) were performed to verify the identified Dot1p phospho-sites. This entry contains...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-29 | PXD040407 | Pride
Histone methyltransferase Yeast Phosphorylation 
UnknownEvolutionary analysis of proline-directed phosphorylation sites in the mammalian growth cone identified using phosphoproteomics.
Not available
S-EPMC6545026 | biostudies-literature
ProteomicsRegulation of Glycogen Synthase kinase 3beta by phosphorylation and O-beta-linked N-acetylglucosaminylation: implications on tau protein phosphorylation
Glycogen synthase kinase 3 (GSK3) plays a pivotal role in signaling pathways related to insulin metabolism and in the pathogenesis of Alzheimer s disease (AD) and other neurodegenerative disorders. More particularly, the GSK3beta isoform is involved in AD-associated tau pathology as one of the major...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-09 | MSV000094049 | MassIVE
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