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ProteomicsProlyl hydroxylation regulates protein degradation, synthesis and splicing in human induced pluripotent stem cell-derived cardiomyocytes
Protein hydroxylases are oxygen and alpha-ketoglutarate-dependent enzymes that catalyze hydroxylation of amino acids such as proline, thus linking oxygen and metabolism to enzymatic activity. Prolyl hydroxylation is a dynamic post-translational modification that regulates protein stability and prote...
ORGANISM(S): Homo sapiens (Human) 
2016-05-06 | PXD003621 | Pride
Lc-ms/ms Amino acid labeling Prolyl hydroxylation Ipsc-derived cardiomyocytes 
TranscriptomicsTuning the transcriptional response to hypoxia through HIF prolyl- and asparaginyl-hydroxylase inhibition:Sequencing Data
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an /-heterodimeric transcription factor that regulates the expression of hundreds of genes in a context dependent manner. A hypoxia-sensing component of the HIF system involves oxygen-dependent ca...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-MTAB-4264 | biostudies-arrayexpress
ProteomicsDifferential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases
The hydroxylation of proline residues to 4-trans-hydroxyproline (Hyp) is a common post-translational protein modification in plants, mediated by prolyl 4-hydroxylases (P4Hs). Hyps predominantly occur in a group of cell wall proteins, the Hydroxyproline-rich glycoproteins (HRGPs), where they are freq...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) 
2024-08-10 | PXD051497 | Pride
O-glycosylation Posttranslational protein modification Erythropoietin Prolyl-hydroxylation Biopharmaceutical Plant-made pharmaceutical 
ProteomicsProlyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer
Protein hydroxylation extensively regulates cellular signaling by affecting protein stability, protein-protein interaction and protein activity, and its dysregulation contributes to the pathogenesis of various diseases including cancers. However, because of the transient nature of the enzyme-substra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-02 | MSV000086231 | MassIVE
ProteomicsLack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Hypoxia Inducible Factor (HIF) prolyl hydroxylase domain (PHD) enzymes catalyse the posttranslational hydroxylation of conserved prolyl residues in the alpha-subunit of the HIF transcription factor. These modifications, which promote the degradation of HIF-alpha subunits by the pVHL E3 ligase comple...
ORGANISM(S): Homo sapiens (Human) 
2019-08-30 | PXD013112 | Pride
Human Lc-msms In vitro Phd enzyme Prolyl hydroxylation 
ProteomicsProline hydroxylation of collagens in prolyl 4-hydroxylase mutant mice
Collagen from the skin of wild type and prolyl 4-hydroxylase mutant mice was extracted and proline hydroxylation of the collagen-derived peptides were analyzed by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2018-04-10 | PXD008802 | Pride
Mouse Collagen prolyl 4-hydroxylase 
Proteomicsfission yeast prolyl hydroxylome
To discover the fission yeast prolyl hydroyxlome. Five biological replicates of WT and Ofd1D cells were cultured. The whole cell lysates were analysed by TMT mass spectrometry for prolyl hydroxylation
ORGANISM(S): Schizosaccharomyces pombe 927 
2022-03-03 | PXD009371 | Pride
Fission yeast 2-oxoglutarate oxygenase Prolyl hydroxylation 
ProteomicsProlyl Hydroxylase Substrate Adenylosuccinate Lyase Is An 2 Oncogenic Driver In Triple Negative Breast Cancer
Protein hydroxylation extensively regulates cellular signaling by affecting protein stability, activity, and interactome, therefore contributing to the pathogenesis of various diseases including cancers. However, because of the transient nature of the hydroxylase-substrate interaction, identifying n...
ORGANISM(S): Homo sapiens (Human) 
2019-11-20 | PXD015790 | Pride
Egln2 prolyl hydroxylase Protein hydroxylation Adenylosuccinate lyase (adsl) 
UnknownDifferential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases.
Not available
S-EPMC11252719 | biostudies-literature
ProteomicsProduction of recombinant human collagen in Physcomitrella
A hydrophilic region encompassing 334 amino acids from human type III collagen was produced in Physcomitrella bioreactors and analyzed with respect to prolyl-hydroxylation.
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) 
2026-02-09 | PXD071319 | Pride
Col3a1 Moss bioreactor Physcomitrella Prolyl hydroxylated collagen 
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