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TranscriptomicsTemperature-dependent transcriptional response under anaerobic C and N limitations in Yeast
The global transcriptional response of Saccharomyces cerevisiae was investigated in low temperature chemostat cultures grown in carbon or nitrogen limitation. During steady state chemostats, the growth rates and in vivo fluxes were kept constant however the growth-limiting nutrient was significantly...
ORGANISM(S): Saccharomyces cerevisiae 
2007-01-20 | E-GEOD-6190 | biostudies-arrayexpress
TranscriptomicsEngineering topology and kinetics of sucrose metabolism in Saccharomyces cerevisiae for improved ethanol yield
Sucrose is a major carbon source for industrial bioethanol production by Saccharomyces cerevisiae. In yeasts, two modes of sucrose metabolism occur: (i) extracellular hydrolysis by invertase, followed by uptake and metabolism of glucose and fructose, and (ii) uptake via sucrose-H+ symport followed b...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-05 | E-GEOD-30535 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae during prolonged maltose limited cultivation
Prolonged cultivation (>25 generations) of Saccharomyces cerevisiae in aerobic, maltose-limited chemostat cultures led to profound physiological changes. Maltose hypersensitivity was observed when cells from prolonged cultivations were suddenly exposed to excess maltose. This substrate hypersensitiv...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8897 | biostudies-arrayexpress
Transcriptomicsin vivo Bap exposure
Gene expression changes to the chemical compound BaP in livers of wildtype and Xpa-/-p53+/- mice
ORGANISM(S): Mus Musculus 
2014-06-01 | E-MTAB-1247 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast to investigate the involvement of Snf7 and Rim101 in regulation of TIR1 and anaerobically up-regulated genes
Despite the scientific and applied interest in anaerobic metabolism of Saccharomyces cerevisiae, not all genes whose transcription is up-regulated under anaerobic conditions have yet been linked to known transcription factors. Experiments with a reporter construct in which the promoter of the anaero...
ORGANISM(S): Saccharomyces cerevisiae 
2009-10-02 | E-GEOD-18128 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast grown in a three-factor design to study the relationship between specific growth rate and genome-wide gene expression
A three-factor design was applied to study the relationship between specific growth rate and genome-wide gene expression in 36 steady-state chemostat cultures of Saccharomyces cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae 
2009-01-15 | E-MTAB-78 | biostudies-arrayexpress
TranscriptomicsEngineering acetyl-CoA supply: Functional expression of a bacterial pyruvate-dehydrogenase complex in the cytosol of Saccharomyces cerevisiae
The energetic (ATP) cost of biochemical pathways critically determines the maximum yield of metabolites of vital or commercial relevance. Cytosolic acetyl-CoA is a key precursor for biosynthesis in eukaryotes and for many industrially relevant product pathways that have been introduced into Saccharo...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-04 | E-GEOD-59814 | biostudies-arrayexpress
TranscriptomicsGenotoxic Carcinogen response in primary mouse hepatocytes
Gene expression changes to several compounds in primary hepatocytes of wildtype and Xpa-/-p53+/- mice
ORGANISM(S): Mus musculus 
2018-04-06 | E-MTAB-665 | biostudies-arrayexpress
TranscriptomicsFlusilazole dose response in zebrafish embryo
The zebrafish embryotoxicity test (ZET) is considered as a useful alternative model in predictive toxicology. Currently, morphological assessment of the embryo is the main readout for this assay. However, implementation of transcriptomics may help to detect more subtle effects which may increase the...
ORGANISM(S): Danio rerio 
2012-03-21 | E-MTAB-832 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae to investigate formaldehyde as source of free-energy during growth on glucose
Previously, it has been demonstrated that formate can be utilized by Saccharomyces cerevisiae as additional energy source using cells grown in a glucose-limited chemostat. Here, we investigated utilization of formaldehyde as co-substrate. Since endogenous formaldehyde dehydrogenase activities were i...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-18 | E-GEOD-8902 | biostudies-arrayexpress
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