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OtherMolecular consequences of proprotein convertase 1/3 inhibition in macrophages for application to cancer immunotherapy: a proteomic study
Data from ProteomeXchange, PXD ID: PXD001984. File: KO_LPS1.mzml. Published as part of Mol Cell Proteomics. 2015 Sep 1 . From the Abstract: {{i}} ... Here, we investigated the intracellular impact of the down-regulation of the proprotein convertase 1/3 in NR8383 macrophages. A complete proteomic st...
ORGANISM(S): Mus_musculus_viruses, Rabbit_calicivirus_australia_1_mic_07_uid33267, Rattus_norvegicus_papillomavirus_1_ees_2009_uid40233, Rat_coronavirus_parker_uid39313, Rat 
GPM32310023533 | GPMDB
Resource Reanalysis 
ProteomicsA novel treatment for glioblastoma based on Taxol activation of PC1/3-depleted macrophages: evidence from a proteomic and functional study.
Tumor-associated macrophages contribute to tumor pathogenesis and represent an attractive therapeutic target. We report that the proprotein convertase PC1/3 inhibits the TLR4 Myd88-pathway induced in macrophages by the anti-cancer agent Taxol. Thus, PC1/3 knock-down in these cells exacerbates the TL...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-03-19 | PXD004444 | Pride
Taxol Macrophage Intracellular trafficking Shotgun proteomic Tlr4 signaling Calcium Tumors Stat3 Proprotein convertase pc1/3 
UnknownHysteretic behavior of proprotein convertase 1/3 (PC1/3).
Not available
S-EPMC3174183 | biostudies-literature
UnknownThe proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
Not available
S-EPMC4725977 | biostudies-literature
UnknownMolecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study.
Not available
S-EPMC4638031 | biostudies-literature
ProteomicsMSP-MS of PC1 and PC2 pH 5.5 at 37C
MSP-MS of PC1 and PC2 pH 5.5 at 37C. Part of Neuropeptide processing study
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
MSV000088092 | MassIVE
ProteomicsHistone proteomic associated with epigenetic studies revealed a Ghost proteome in PC1/3 KD macrophages involved in anti - tumoral resistance under IL - 10 stimulation
In our previous work, our investigation on macrophages has allowed us to show that the inhibition of the enzyme proprotein convertase (PC1/3) controls the activation of macrophages. We demonstrated that PC1/3 knockdown (KD) in macrophages would exhibit an increased secretion of pro-inflammatory and ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-02-12 | PXD020610 | Pride
Macrophage Lc-msms Altprots Histone Epigenetic 
UnknownDisruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
Not available
S-EPMC3340273 | biostudies-literature
UnknownProprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.
Not available
S-EPMC3634814 | biostudies-literature
UnknownBiochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph.
Not available
S-EPMC4138575 | biostudies-literature
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