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MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Untargeted assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prosta...

2023-04-17 | MTBLS6039 | MetaboLights
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Targeted organic acid assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
ProteomicsUrinary Metabolomic and Proteomic Analyses of a Prostatic Inflammation Mouse Model
Lower urinary tract symptoms (LUTS) relate to storage and/or voiding disturbances which are common among aging men. Disease etiology is largely unknown, and diagnosis is currently based on subjective symptom scores. While mainstay treatments can be ineffective and bothersome, biomarker discovery eff...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-03 | PXD018023 | Pride
Proteomics Prostatic inflammation Isobaric labeling Metabolomics Urine Mass spectrometry Metandem Label free. Lower urinary tract symptoms 
MetabolomicsDistinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones

INTRODUCTION: Prostatitis is likely to occur in younger or middle-aged men, while prostate cancer is likely to occur in older men. Although amino acids and lipids as biomarkers of prostate cancer have been examined using prostate cancer cell lines/tissues, no previous studies hav...

2020-11-04 | MTBLS2028 | MetaboLights
TranscriptomicsTranscription profiling by array of human prostate from patients with a previous diagnosis of Prostatic Intraepithelial Neoplasia and following consumption of high glucosinolate broccoli or peas to investigate interactions with the GSTM1 genotype
Twenty-two male volunteers aged 30-70 years with a previous diagnosis of Prostatic Intraepithelial Neoplasia (PIN) were recruited by a consultant urologist at Norfolk and Norwich University Hospital NHS Trust. Ethical approval for the trial was obtained from the Norfolk Research Ethics Committee (re...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-MEXP-1243 | biostudies-arrayexpress
UnknownProstate-Specific Deletion of Cdh1 Induces Murine Prostatic Inflammation and Bladder Overactivity.
Not available
S-EPMC7745638 | biostudies-literature
GenomicsOsteopontin deficiency leads to the resolution of prostatic fibrosis and inflammation
Osteopontin deficiency leads to the resolution of prostatic fibrosis and inflammation
PRJNA744485 | ENA
UnknownUrinary Metabolomic and Proteomic Analyses in a Mouse Model of Prostatic Inflammation.
Not available
S-EPMC8052098 | biostudies-literature
ProteomicsIdentification of Altered Proteins in the Plasma of Rats with Chronic Prostatic Inflammation Induced by Estradiol Benzoate and Sex Hormones
The cause of non-bacterial chronic prostatitis is unknown, yet its prevalence accounts for more than 90% of all prostatitis cases. Whole blood, plasma, and serum have been used to identify prostate cancer biomarkers; however, few studies have performed protein profiling to identify prostatitis bioma...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-10 | PXD024422 | Pride
Estradiol Proteomics Plasma Prostate Rats Testosterone Estradiol benzoate Chronic inflammation 
TranscriptomicsProstates of rats with induced partial bladder outlet obstruction and the effect of Eviprostat on those changes
Prostatic inflammation plays a role in the progression of benign prostatic hyperplasia (BPH). Eviprostat is an antiinflammatory and antioxidant phytotherapeutic agent widely used to treat lower urinary tract symptoms in BPH. However, because Eviprostat is a mixture of compounds from multiple natural...
ORGANISM(S): Rattus norvegicus 
2010-04-09 | E-GEOD-16063 | biostudies-arrayexpress
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