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ProteomicsSystematic Evaluation of Data-Independent Acquisition for Sensitive and Reproducible Proteomics – a Prototype Design for a Single Injection Assay
This dataset includes twelve DIA methods with various mass-isolation windows that analyze precursor ranges from 400-1250 m/z as well as shotgun acquired data with the same instrument and LC gradient. The mass-isolation windows analyzed included 3, 6, and 26 m/z widths. Each 3 m/z window method ana...
ORGANISM(S): Escherichia coli 
2015-12-02 | PXD002688 | Pride
Protalizer  dia  swath  pacific  label-free quantification 
ProteomicsSpatially-targeted proteomics of S. aureus abscess formation
Staphylococcus aureus is a major contributor of healthcare-associated infections and able to withstand numerous frequently used antibiotics. In order to develop novel treatment approaches, a deeper understanding of the complex interaction between host and pathogen is required. This is particularly t...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2020-11-30 | PXD019920 | Pride
Kidney Microlesa Lc-ms/ms S. aureus 
ProteomicsApplication of SPOT to Zn-treated HL-60 cells for multi-omics mechanism discovery
Application of SPOT to Zn-treated HL-60 cells for multi-omics mechanism discovery. A time-resolved, multi-omics experiment using an aumtomated, unified sample preparation platform
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD009149 | Pride
Multi-omics Hl-60 cells Spot 
ProteomicsQuantitative proteomics analysis of COVID-19 infected hamster lung tissue
The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here we show that the hypoxia-inducible factor (HIF-1α) transcriptional pathway is activated, perhaps due to a lack of oxygen or an accumulation of mitochondrial reactive oxygen species...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2023-03-10 | PXD036862 | Pride
Covid-19 Lung tissue 
ProteomicsQuantitative Proteomic Analysis of an Alexander Disease Murine Model with Severe Reactive Gliosis
We performed label-free micro-data-independent acquisition (µDIA) to assay brain proteins from a severe model of Alexander disease (AxD, lethal at postnatal day ~35). Of the 5,005 proteins quantified, we observed upregulation of adipocytokine signaling, PPAR, insulin resistance, and glutathione pat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-30 | PXD021884 | Pride
Reactive gliosis Alexander disease Parallel reaction monitoring Data-independent acquisition Brain proteome 
ProteomicsQuantitative proteomics study of Mecp2 KO versus wild type mice
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. RTT is characterized by having apparently normal development until 6-18 months, when a progressive decline in motor and language functions begins and breathing abnormalities and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-02 | PXD006460 | Pride
Dia Mouse brain cortex Rett syndrome 
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