Sort   by:  
 Page size 
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
ProteomicsTunable Plasma Coating Method Modulates Surface Charge and Protein Corona of Cell-Derived Nanovesicles for Improved Systemic Drug Delivery
Tunable Plasma Coating Method Modulates Surface Charge and Protein Corona of Cell-Derived Nanovesicles for Improved Systemic Drug Delivery
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD071878 | Pride
Human Lc-ms 
MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
ProteomicsProteomics and metabolomics of different delivery modes in human pregnancy
This project investigates the impact of different delivery modes and labor on maternal and neonatal health by analyzing 40 participants, including 16 spontaneous vaginal deliveries (VD), 16 prelabor cesarean deliveries (CS), and 8 intrapartum cesarean sections (Intra_CS). Using label-free proteomics...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058131 | Pride
Proteomics   metabolomics   delivery modes 
GenomicsHomo sapiens
Cationic lipid protein delivery
PRJNA507860 | ENA
GenomicsRejuvenation of the Aged Cerebrovascular System via Protein Corona–Guided Fusogenic Liposome Delivery
Rejuvenation of the Aged Cerebrovascular System via Protein Corona–Guided Fusogenic Liposome Delivery
PRJNA1439956 | ENA
ProteomicsTumor Agnostic Drug Delivery with Dynamic Nanohydrogels
RNA interference (RNAi) holds unique potential as a clinically viable modality to pharmacologically regulate oncogenes in sequence-specific manner. However, systemic delivery of RNAi to tumors encounters myriad obstructions, and strategies to overcome such barriers have largely consisted of academic...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-12 | PXD070605 | Pride
Nanohydrogels Rnai Plasma Drug delivery 
ProteomicsIonizable polymeric micelles (IPMs) for efficient siRNA delivery
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance. We design three ionizable oligo-mers (IOs) that, with PLA-PEG, form Ionizable Polymeric Micelles (IPMs), a potential siRNA delivery system, which can achie...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD057444 | Pride
Hsp47 Protein corona Hmgb1 Hepatic fibrosis Fibroblast activation protein inhibitor (fapi) Nucleic acid delivery Ionizable polymeric micelles (ipms) Hepatic stellate cells 
UnknownAgile delivery of protein therapeutics to CNS.
Not available
S-EPMC4142106 | biostudies-literature
ProteomicsExamining the modality-dependent target specificity of bioPROTACs by analysing global proteome changes following mRNA-encoded or recombinant protein biodegrader delivery.
Proteolysis targeting chimeras (PROTACs) have surged in popularity as a drug modality owing to their ability to degrade pathogenic proteins. Despite their advantages over conventional inhibitors, PROTAC discovery still requires high-affinity warheads, but ligands for undruggable proteins are difficu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD049388 | Pride
Recombinant protein Proteomics Lipid nanoparticle Protac Gtpase Mass spectrometry Ras Drug delivery Bioprotac Mrna Cytosolic delivery Kras 
Sort   by:  
 Page size