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Transcriptomicsp53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization
p53 regulates a distinct subset of skeletal muscle mRNAs during immobilization-induced skeletal muscle atrophy For additional details see Fox et al, p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 1;30...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-62897 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human vastus lateralis skeletal muscle (knee) after 48 h of immobilization
Our results suggest that 48h of immobilization increases expression of mRNA for components of the UPP and MT function while decreasing mRNA and protein for components involved in ECM integrity. We hypothesized that 48h of immobilization would increase gene expression and respective protein products ...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-5110 | biostudies-arrayexpress
TranscriptomicsLimb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
Advancements in animal models and cell culture techniques have been invaluable in the elucidation of molecular events and mechanisms regulating muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine a...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14901 | biostudies-arrayexpress
ProteomicsSite-specific immobilization of the endosialidase for studying polysialic acid reveals QSOX2 is a novel polysialylated protein
Polysialic acid (polySia) is a linear polymer of α2,8-linked sialic acid residues that is of fundamental biological interest due to its pivotal roles in the regulation of the nervous, immune, and reproductive systems in healthy human adults. PolySia is also dysregulated in several chronic diseases, ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD046194 | Pride
Qsox2 Proteomics Endon Protein immobilization Biotinylation 
Transcriptomics48h Immobilization in human
Our results suggest that 48h of immobilization increases expression of mRNA for components of the UPP and MT function while decreasing mRNA and protein for components involved in ECM integrity. We hypothesized that 48h of immobilization would increase gene expression and respective protein products ...
ORGANISM(S): Homo sapiens 
2006-06-20 | GSE5110 | GEO
TranscriptomicsTranscription profiling of rat duodenum during immobilization
In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Experiment Overall Design: Total RNA was extracted from the duodenal mucosa with an acid guanidinium thiocyanate-phenol-chloroform mixtur...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4426 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of in rat adrenal medulla after exposure to single and repeated immobilization stress
Microarray profiling single and repeated immobilization stress responses in gene expression in rat adrenal medulla Experiment Overall Design: Immobilization stress (IMO) was performed with 2-hour once and 2-hour daily for 6 days repeated. Control groups were not exposed to stress (absolute controls)...
ORGANISM(S): Rattus norvegicus 
2008-10-18 | E-GEOD-8184 | biostudies-arrayexpress
TranscriptomicsSystems biology analysis of Korean red ginseng effects on Immobilization stressed mice brain
Here we present molecular mechanisms of Korean red ginseng (KRG) on immobilization stresses Keywords: stress response Mice were divided into three groups (3 mice / group): control, stress + no treat, and stress + Korean Red Ginseng (KRG, 100 mg). Stress + KRG group were given KRG 100 mg orally for...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-12656 | biostudies-arrayexpress
ProteomicsImmobilization of Ce(IV)-substituted polyoxometalate on ethylenediamine-functionalized graphene oxide for the isolation of intact phosphoproteins
Phosphorylation of protein plays a key role in the regulation of many biological processes. Herein, a simple approach is developed by immobilization of Ce(IV)-substituted polyoxometalate on ethylenediamine-functionalized graphene oxide (CeEGO) as adsorbent for selective isolation of intact phosphop...
ORGANISM(S): Homo Sapiens 
2018-07-20 | PXD010524 |
UnknownSolid-phase synthesis of protein-polymers on reversible immobilization supports.
Not available
S-EPMC5829226 | biostudies-literature
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