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ProteomicsExpanding the substantial interactome of NEMO using protein microarrays
Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals transmitted from upstream sensors to the downstr...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-19841 | biostudies-arrayexpress
GenomicsExpanding the substantial interactome of NEMO using protein microarrays
Expanding the substantial interactome of NEMO using protein microarrays
PRJNA122063 | ENA
ProteomicsEnzymatic Analysis of WWP2 E3 Ubiquitin Ligase Using Protein Microarrays Identifies Autophagy-Related Substrates
WWP2 is a HECT E3 ligase that targets protein Lys residues for ubiquitination. As a member of the NEDD4 family of E3 ligases, WWP2 is comprised of an N-terminal C2 domain, four central WW domains, and a C-terminal catalytic HECT domain. The peptide segment between the middle WW domains, the 2,3-link...
ORGANISM(S): Escherichia coli 
2022-05-20 | PXD031703 | Pride
Ubiquitination Protein microarray Wwp2 Autophagy receptor Lc-msms 
ProteomicsAutoantibodies are abundant in all human sera: a demographic characterization via protein microarrays
Human serum samples were probed onto human protein microarrays in order to ascertain the number and diversity of naturally ocurring self-reactive IgG autoantibodies. In the study presented here, 166 human serum samples were probed onto human protein microarrays in order to identify self-reactive IgG...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-39087 | biostudies-arrayexpress
TranscriptomicsIdentification of Proteins Binding Coding and Non-coding Human RNAs using Protein Microarrays
We describe a refined approach to identify new human RNA-protein interactions. In vitro transcribed labeled RNA is bound to ~9,400 human recombinant proteins spotted on protein microarrays. This approach identified 137 RNA-protein interactions for 10 human coding and non-coding RNAs, including an in...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-34794 | biostudies-arrayexpress
UnknownProtein Profiling Gastric Cancer and Neighboring Control Tissues Using High-Content Antibody Microarrays.
Not available
S-EPMC5040966 | biostudies-literature
TranscriptomicsAnalysis of fetal livers from male mice after protein-restricted diet in mothers
Prenatal nutrition as influenced by nutritional status of the mother has been identified as a determinant of adult disease. Feeding low-protein diets during pregnancy in rodents is a well-established model to induce “programming” events in offspring. We hypothesized that protein restriction would in...
ORGANISM(S): Mus musculus 
2009-11-02 | E-GEOD-15280 | biostudies-arrayexpress
GenomicsThe REL domain of the NFATc2 protein binding to four types of DNA using protein binding microarrays
The REL domain of the NFATc2 protein binding to four types of DNA using protein binding microarrays
PRJNA413374 | ENA
ProteomicsComparison of protein profiles in the serum of NPC patients with different prognosis by high-throughput protein microarrays
High levels of c-Src in serum of patients with NPC was independent prognostic indicators for poor outcome of patients. In this study, eight NPC patients with or without distant metastasis, followed up more than five years, was used to acquire protein profiles in serum to find out serum biomarkers to...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-68764 | biostudies-arrayexpress
UnknownProtein microarrays for personalized medicine.
Not available
S-EPMC7108201 | biostudies-literature
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