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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
GenomicsProtein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
PRJNA854161 | ENA
UnknownSAR by kinetics for drug discovery in protein misfolding diseases.
Not available
S-EPMC6187117 | biostudies-literature
TranscriptomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during ageing and in protein aggregation-associated diseases. This RNA-seq study in Saccharomyces cerevisiae investigated the role of Tsa1, which is a member of the highly ...
ORGANISM(S): Saccharomyces cerevisiae 
2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress
ProteomicsExpression dynamics in mammalian cells responding to protein misfolding stress
The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth analysis of a cervical cancer cell line responding to protein misfolding stress induced by dithiothreitol treatment, quantifying the dynamics of mRNA and p...
ORGANISM(S): Homo sapiens (Human) 
2016-03-14 | PXD002039 | Pride
Human Lc-msms Protein misfolding stress Hela 
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
GenomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Redox control of the cAMP/PKA pathway during protein misfolding stress
PRJEB39415 | ENA
GenomicsDELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
PRJNA1141402 | ENA
UnknownProbing the origin of prion protein misfolding via reconstruction of ancestral proteins.
Not available
S-EPMC9667828 | biostudies-literature
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