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MetabolomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME (Gasdermin E) is a critical protein known for its role in pyroptosis, a form of programmed cell death associated with inflammation. We demonstrated that GSDME as a crucial mediator in muscle repair, particularly in the context of muscle damage induced by cardiotoxin (CTX). Specifically, we fou...
2026-01-05 | MTBLS10509 | MetaboLights
MetabolomicsRepair-Associated Macrophages Increase after Early-phase Microglia Attenuation to Promote Ischemic Stroke Recovery

Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 ...

2025-02-20 | MTBLS12240 | MetaboLights
MetabolomicsHUMSCs repair CCl4-induced chronic liver injury in rats via metabolic regulation

To explore the effect of human umbilical cord mesenchymal stem cells (HUMSCs) on repairing CCl4-induced chronic liver injury in rats by intravenous injection and analyze the promising metabolites.

2026-02-03 | MTBLS13826 | MetaboLights
MetabolomicsUrinary metabolomics reveals kynurenine pathway perturbation in newborns with transposition of great arteries after surgical repair

INTRODUCTION: Transposition of the great arteries (TGA) is a cyanotic congenital heart defect that requires surgical correction, with the use of cardiopulmonary-bypass (CPB), usually within 3 weeks of life. The use of CPB in open heart surgery results in brain hypoperfu...

2020-04-15 | MTBLS946 | MetaboLights
MetabolomicsWLJP-025p Promote Colonic Epithelial Repair in Ulcerative Colitis through Fatty Acid Oxidation by Regulating Microbial-involvemented SPD Production

BACKGROUND & AIMS: Ulcerative colitis (UC) poses a serious threat to human health. WLJP-025p, a polysaccharide component of Lonicera japonica thunb. has been confirmed to have anti-inflammatory and immunomodulatory effects. This study intends to explore the effects and mechanism of WLJP-025p ...

2026-05-16 | MTBLS12400 | MetaboLights
MetabolomicsBacteria encode their own post-mortem protein catabolism to enable nutrient recycling
For many organisms, death is a tangible, visible event. In bacteria, death can be a natural or an induced process 1. Death permits genes conferring a survival advantage to be selected in a bacterial population. Furthermore, biomolecule recycling from dead bacteria is crucial under nutrient limitatio...
2025-01-23 | MTBLS10044 | MetaboLights
TranscriptomicsGlobal Genome-Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. We measured the distribution of nucleotide excision repair (NER) rates for UV induced lesions throughout the yeast genome. By plotting these repair rates in r...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-21 | E-MTAB-4641 | biostudies-arrayexpress
GenomicsCovalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair
Based on the hypothesis that, enhancing the local concentration of donor oligos could increase the correction rates, we generated and tested novel CRISPR-Cas9 systems, in which the DNA repair template is covalently conjugated to Cas9 (RNPD system). To validate our results from the HEK293T reporter c...
ORGANISM(S): Mus musculus 
2018-06-04 | E-MTAB-6808 | biostudies-arrayexpress
TranscriptomicsCPD-seq mapping of UV damage formation and repair in yeast
UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. We have used a novel high-throughput sequencing method to precisely map UV-induced cyclobutane pyrimidine dimers (CPD...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-19 | E-GEOD-79977 | biostudies-arrayexpress
MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
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