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MetabolomicsDecreased abundance of type III secretion systeminducing signals in Arabidopsis mkp1 enhances resistance against Pseudomonas syringae
Genes encoding the virulence-promoting type III secretion system (T3SS) in phytopathogenic bacteria are induced at the start of infection, indicating that recognition of signals from the host plant initiates this response. However, the precise nature of these signals and whether their concentrations...
2014-06-24 | MTBLS95 | MetaboLights
MetabolomicsSerum LC-MS metabolomics profiling during musk secretion in captive forest musk deer (Moschus berezovskii)
This study investigates serum metabolomic changes associated with musk secretion in captive male forest musk deer (Moschus berezovskii). Paired serum samples were collected before secretion and during secretion and analyzed using LC-MS in both positive and negative ion modes. The study includes biol...
2026-04-23 | MTBLS14280 | MetaboLights
MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
MetabolomicsSelective mTOR inhibition via FLCN drives TFE3-dependent VLDL-TG secretion and protects from MAFLD/MASH
Hepatic lipid homeostasis is controlled by multiple processes, including VLDL-TG secretion. We have previously shown that the FLCN/TFE3 branch of mTORC1 signaling controls hepatic fatty acid oxidation and de novo lipogenesis to protect mice from MAFLD. We now show that the FLCN/TFE3 pathway also con...
2026-09-08 | MTBLS15598 | MetaboLights
MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
MetabolomicsAkkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease
The gut microbiome is a key factor regulating energy-metabolism, glucose tolerance and the immune system. Akkermansia muciniphila has been identified as being beneficial gut bacterium for metabolic diseases, including obesity and type 2 diabetes (T2D); however, the molecular mechanisms involved in h...
2021-01-13 | MTBLS1824 | MetaboLights
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
MetabolomicsMetabolomics analysis was used to resolve metabolites affecting the protein oil content of soybean.
Soybean (Glycine max (L.)) originated in China more than 5000 years ago, and the country is currently the third largest producer of soybeans in the world (Hymowitz et al., 2015). Based on a wild soybean Chromosome Segment Substitution Line (CSSL) population were constructed by crossing with the cult...
2024-11-13 | MTBLS9424 | MetaboLights
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